DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hnrnpa1 and Hrb87F

DIOPT Version :9

Sequence 1:	NP_001034218.1	Gene:	Hnrnpa1 / 15382	MGIID:	104820	Length:	373	Species:	Mus musculus
Sequence 2:	NP_001163602.1	Gene:	Hrb87F / 48535	FlyBaseID:	FBgn0004237	Length:	385	Species:	Drosophila melanogaster

Alignment Length:	390	Identity:	194/390 - (49%)
Similarity:	247/390 - (63%)	Gaps:	43/390 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 ESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVD 69
            |...|||||||||||||.:.|||:.|::|||:||.:.|.|||:||.|||||||||:||:....:|
  Fly    15 EEITEPEQLRKLFIGGLDYRTTDDGLKAHFEKWGNIVDVVVMKDPKTKRSRGFGFITYSQSYMID 79

Mouse    70 AAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVI 134
            .|.||||||:|||.|||||||.|::...|.|..||||:||||:::|.:|..||:||:.:|:|..:
  Fly    80 NAQNARPHKIDGRTVEPKRAVPRQEIDSPNAGATVKKLFVGGLRDDHDEECLREYFKDFGQIVSV 144

Mouse   135 EIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGS 199
            .|::|:.:||||||||:.|||:|.||||::||.|::.....:|:||::||:|     .::|  |.
  Fly   145 NIVSDKDTGKKRGFAFIEFDDYDPVDKIILQKTHSIKNKTLDVKKAIAKQDM-----DRQG--GG 202

Mouse   200 GNFGGGRGGGFGGNDNFGRGGNFSGRGGFGG---SRGGGGYGGSGDGYNGFGNDGG-YGGGSPGY 260
            |..||.|.||.||..:.|:||     ||:||   ..|||.:||:|.| .||||.|| :|||..|.
  Fly   203 GGRGGPRAGGRGGQGDRGQGG-----GGWGGQNRQNGGGNWGGAGGG-GGFGNSGGNFGGGQGGG 261

Mouse   261 SGG-SRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGGFGGGS-----GSNFGGGGSYNDFGNY 319
            ||| ::..||||..:.|||.|.||.       |||||||:|||:     |.|.||||....|||.
  Fly   262 SGGWNQQGGSGGGPWNNQGGGNGGW-------NGGGGGGYGGGNSNGSWGGNGGGGGGGGGFGNE 319

Mouse   320 NNQSSNFGPMKGGNFGGRSSGPY--GGGGQYFAKPRNQGG----------YGGSSSSSSYGSGRR 372
            ..||...||.:..|||.....||  ||||..|.| .||||          .||.....:.|.|.|
  Fly   320 YQQSYGGGPQRNSNFGNNRPAPYSQGGGGGGFNK-GNQGGGQGFAGNNYNTGGGGQGGNMGGGNR 383

Mouse 373 372
Fly 384 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnrnpa1	NP_001034218.1	RRM1_hnRNPA1	12..92	CDD:241205	54/79 (68%)
		RRM2_hnRNPA1	105..181	CDD:241024	37/75 (49%)
		HnRNPA1	310..345	CDD:288479	15/36 (42%)
Hrb87F	NP_001163602.1	RRM1_hnRNPA_like	25..102	CDD:241022	51/76 (67%)
Hrb87F	NP_001163602.1	RRM_SF	116..188	CDD:302621	34/71 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6804
eggNOG	1	0.900	-	-		E33208_3BA81
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	348	1.000	Inparanoid score	I2280
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46466
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	1	1.000	-	-		FOG0000779
OrthoInspector	1	1.000	-	-		mtm8743
orthoMCL	1	0.900	-	-		OOG6_103644
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2767
SonicParanoid	1	1.000	-	-		X431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.810