Protein Alignment SLC36A2 and VGAT

DIOPT Version :10

• Sequence 1: NP_861441.2
• Gene: SLC36A2 / 153201
• HGNCID: 18762
• Length: 483
• Species: Homo sapiens
• Sequence 2: NP_610938.1
• Gene: VGAT / 36574
• FlyBaseID: FBgn0033911
• Length: 549
• Species: Drosophila melanogaster
• Alignment Length: 488
• Identity: 117/488 - (23%)
• Similarity: 202/488 - (41%)
• Gaps: 67/488 - (13%)

Human     5 KSTEG-PQGAVAIKLDLMSPPESAKKLENKDSTFLDESPSESAGLKKTKGITVFQALIHLVKGNM 68
            :.|:| .||::|                ::.|:|:.|  .|..|..|   |..|||..::.....
  Fly   112 QQTDGFRQGSIA----------------SEGSSFVCE--GEGGGGCK---IDEFQAAWNVTNAIQ 155

Human    69 GTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAQRFCKRLNKPFMDYGDTVMHGLEA 133
            |..|:.||.||.:.| ....::::.:..|.|:...:||:|       |.:|....|..|......
  Fly   156 GMFIVSLPFAVLHGG-YWAIVAMVGIAHICCYTGKVLVQC-------LYEPDPATGQMVRVRDSY 212

Human   134 NPNAWLQNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSTTNNCYSNETVILTPT 198
            ...|.:......|...||...:|..|..|.:|:|...|.|.           ..|..      .:
  Fly   213 VAIAKVCFGPKLGARAVSIAQLIELLMTCILYVVVCGDLLA-----------GTYPQ------GS 260

Human   199 MDSRLYMLSFLPFLVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPD--PSRLPLVAS 261
            .|||.:||....||:.:..:::|::::..|....:|.:|...:|:.|...:|.|  .|::.....
  Fly   261 FDSRSWMLFVGIFLLPMGFLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQIGDWGWSKVRFSID 325

Human   262 WKTYPLFFGTAIFSFESIGVVLP-LENKMKNARHFPAILSLGMSIVTSLYIGMAALGYLRFGDDI 325
            .:.:|:..|..:||:.| .:.|| ||..|.:...|..:|............|...:.:|.|.:|.
  Fly   326 MENFPISLGVIVFSYTS-QIFLPTLEGNMIDRSKFNWMLDWSHIAAAVFKAGFGYICFLTFQNDT 389

Human   326 KASISLNLPNCWLYQSVKLLYIAGILCTYALQFYVPAEIIIPFAI-----SRVSTRWALPLDLSI 385
            :..|:.||.:......|....:...|.:|.|.:|...|::.....     ::..|.|.|..:|.:
  Fly   390 QQVITNNLHSQGFKGMVNFFLVIKALLSYPLPYYAACELLERNFFRGPPKTKFPTIWNLDGELKV 454

Human   386 -----RLVMVCLTCLLAILIPRLDLVISLVGSVSGTALALIIPPLLEVTTFYSEG--MSPLTIFK 443
                 |:.::..|.|:||.||...:::..:||.:||.|:.|.|....:..   :|  :....|.|
  Fly   455 WGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIKI---KGHLLDQKEIAK 516

Human   444 DALISILGFVGFVVGTYQALDELLKS-EDSHPF 475
            |.||..||.:..|:|.|.:.:.|:.: |...||
  Fly   517 DYLIIGLGVLFGVIGIYDSGNALINAFEIGLPF 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC36A2	NP_861441.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..46		4/19 (21%)
		SLC5-6-like_sbd	52..463	CDD:444915	102/425 (24%)
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:444915	100/417 (24%)