DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADRB1 and Octbeta1R

DIOPT Version :9

Sequence 1:	NP_000675.1	Gene:	ADRB1 / 153	HGNCID:	285	Length:	477	Species:	Homo sapiens
Sequence 2:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	151/507 - (29%)
Similarity:	230/507 - (45%)	Gaps:	103/507 - (20%)

- Green bases have known domain annotations that are detailed below.

Human     9 GASEPGNLSSAAPLPDGAATAARLL-------------VPASPPASLLPPASESPEPLSQQWTAG 60
            |.:||  |:|..|:.:.:|:.||.|             ......:|:.....:.....:|...|.
  Fly    29 GTNEP--LASKIPVLEESASHARYLKFIADGLIDEGLGSAVGSGSSIAVSVEDVVAGQAQDIQAS 91

Human    61 MG------------------LLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVM 107
            .|                  .::..|:|..:.||:||||::.:..:|:.:||.|::|||.||:::
  Fly    92 EGSTDDADGSSHLALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLV 156

Human   108 GLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTR 172
            .|..:.|.|::::.|:|.:||..|::|.|.||...||||..||.|::|||.||..|..|..::|:
  Fly   157 ALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQ 221

Human   173 ARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPL 237
            .|...::..||...||:|||||...|: ..::..:...::|..|:|..|:||||.||.:||::|.
  Fly   222 RRVFIMLLMVWLSPALLSFLPICSGWY-TTTENYKYLKSNPHICEFKVNKAYAIVSSSMSFWIPG 285

Human   238 CIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLA 302
            .:|..:|.|:::||.:|.:.:   .|..:...........|.:|       .|||:.....:.::
  Fly   286 IVMLSMYYRIYQEADRQERLV---YRSKVAALLLEKHLQISQIP-------KPRPSIQVEQSTIS 340

Human   303 NGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV-FFNWLG 366
            ..|            ||:||.:||||||..|.:|||||||..:|.:.....:..||.| ...|:|
  Fly   341 TMR------------RERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIG 393

Human   367 YANSAFNPIIYCR-SPDFRKAFQGLL---------CCARRAARRRHATHGDRPRASGCLARPGPP 421
            |.|||.|||||.. :.|||.||:..|         .|.|...|
  Fly   394 YFNSALNPIIYAYFNRDFRAAFKKTLKSLFPYAFYFCRRGRGR---------------------- 436

Human   422 PSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFAS 473
                    |||.|:....|..|      |.||.....|.|:....|....||
  Fly   437 --------DDDRDLEFGGPSRR------GTNGAQRTGSGSAEMANCVNSTAS 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADRB1	NP_000675.1	7tm_4	67..>266	CDD:304433	75/198 (38%)
		7tm_1	75..377	CDD:278431	110/302 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..307		6/37 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..477		14/71 (20%)
		PDZ-Binding	474..477		151/507 (30%)
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	45/118 (38%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	110/302 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5266
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40768
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.970