Protein Alignment ADRB1 and adrb1

DIOPT Version :10

• Sequence 1: NP_000675.1
• Gene: ADRB1 / 153
• HGNCID: 285
• Length: 477
• Species: Homo sapiens
• Sequence 2: XP_031762027.1
• Gene: adrb1 / 116412276
• XenbaseID: XB-GENE-6034588
• Length: 389
• Species: Xenopus tropicalis
• Alignment Length: 415
• Identity: 252/415 - (60%)
• Similarity: 293/415 - (70%)
• Gaps: 57/415 - (13%)

Human    44 PPASESP-EPL---SQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASAD 104
            ||...|| .||   :.|||.||.:|||.|:||||.||::|||||||..|||||||:||.|||.||
 Frog    18 PPTVPSPMHPLPEMTHQWTVGMTMLMAAIILLIVVGNIMVIVAIAKNQRLQTLTNVFITSLACAD 82

Human   105 LVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSL 169
            |:|||.|||.|||:||.|.|.|||.|||.|||||||||||||||||:||:|||:|||||||||||
 Frog    83 LIMGLFVVPLGATLVVSGTWLYGSTFCEFWTSVDVLCVTASIETLCIIAIDRYIAITSPFRYQSL 147

Human   170 LTRARARGLVCTVWAISALVSFLPILMHWWRAESDE-ARRCYNDPKCCDFVTNRAYAIASSVVSF 233
            ||:.||:|:|||||.||||||||||:|||||...|. |.|||.||.|||||||||||||||::||
 Frog   148 LTKGRAKGIVCTVWGISALVSFLPIMMHWWRDTGDPVALRCYEDPGCCDFVTNRAYAIASSIISF 212

Human   234 YVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAAT 298
            |:||.:|.|||:|||:|||||:||||.||.||          |.|.|
 Frog   213 YIPLIVMIFVYIRVFKEAQKQMKKIDKCEGRF----------SHSHV------------------ 249

Human   299 APLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFN 363
              |::||:.:|..|:::..:|||||||||||||.||:|||||||||||..|:|.|:||:||:|.|
 Frog   250 --LSHGRSSRRILSKILVAKEQKALKTLGIIMGTFTMCWLPFFLANVVNVFYRNLIPDKLFLFLN 312

Human   364 WLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAAS 428
            |||||||.||||||||||||||||:.||||.::|.|..|.| |:..|.||           |..:
 Frog   313 WLGYANSMFNPIIYCRSPDFRKAFKRLLCCPKKAERHLHTT-GELSRYSG-----------GFVN 365

Human   429 DDDDDDVVGATPPARLLEPWAGCNG 453
            ..|          ...|..|:.|||
 Frog   366 SLD----------TNALGTWSECNG 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADRB1	NP_000675.1	7tmA_Beta1_AR	59..387	CDD:320624	222/328 (68%)
		TM helix 1	60..86	CDD:320624	18/25 (72%)
		TM helix 2	93..120	CDD:320624	19/26 (73%)
		TM helix 3	131..161	CDD:320624	25/29 (86%)
		TM helix 4	175..193	CDD:320624	14/17 (82%)
		TM helix 5	221..253	CDD:320624	23/31 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	269..307		6/37 (16%)
		TM helix 6	317..347	CDD:320624	25/29 (86%)
		TM helix 7	356..381	CDD:320624	20/24 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	403..477		12/51 (24%)
		PDZ-Binding	474..477
adrb1	XP_031762027.1	7tmA_Beta1_AR	38..336	CDD:320624	222/327 (68%)
		TM helix 1	38..64	CDD:320624	18/25 (72%)
		TM helix 2	71..98	CDD:320624	19/26 (73%)
		TM helix 3	109..139	CDD:320624	25/29 (86%)
		TM helix 4	153..171	CDD:320624	14/17 (82%)
		TM helix 5	200..232	CDD:320624	23/31 (74%)
		TM helix 6	266..296	CDD:320624	25/29 (86%)
		TM helix 7	305..330	CDD:320624	20/24 (83%)