Protein Alignment JAKMIP1 and Pif1A

DIOPT Version :10

• Sequence 1: NP_001092903.1
• Gene: JAKMIP1 / 152789
• HGNCID: 26460
• Length: 831
• Species: Homo sapiens
• Sequence 2: NP_001189195.2
• Gene: Pif1A / 8674049
• FlyBaseID: FBgn0261015
• Length: 1264
• Species: Drosophila melanogaster
• Alignment Length: 1079
• Identity: 229/1079 - (21%)
• Similarity: 400/1079 - (37%)
• Gaps: 331/1079 - (30%)

Human    16 TDAVQMANEELRAKLTSIQI------------EFQQEKSKVGKLRERLQEAKLERE--------- 59
            |......|:|.|.::..||:            .|:.||......:::|.:|:.:||
  Fly    74 TSVGDTVNQEKRTRIEGIQLHCRGKLRPKETQSFEAEKGPSAGSQKQLGKAEKDRERPVIIGGVT 138

Human    60 -------------QEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIK----- 106
                         ::.:.:...|.:|.| |.|:...|:..|:..||.  |:.|.|..:.:
  Fly   139 TTNVIAAPPQRIKRKLQENMDTIQKLNA-LTEQLRLEVNELKSSLIT--ERGAVRALRAQNDADS 200

Human   107 ---EGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAF---DG----ERLRLQQEILELKAA 161
               :.|:::||.||.:.:  .::.:|.|:  |:..|:..|.   ||    |..||..||..||.|
  Fly   201 RRWKSEVKKLQHTLEMAK--KSNGIKKAI--ESGPESSGAHVTADGLINYEIQRLTNEIAVLKEA 261

Human   162 RKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL 226
            .:..||......|||:.||||:|....|:::.:..|::..:.:|.||::|||.|:|.|..|.|:|
  Fly   262 NRNKEEKTQIMGQADRLKAADMRQLKNAYENRLTHIQKSAKIEITRLLEEIKTKERNIGQLRKDL 326

Human   227 GVQAGQTQKLLLQKEA-----------------------------------------LDEQ---- 246
              .|.|:.|.|.|.||                                         :.||
  Fly   327 --LALQSPKKLKQNEAKVPATTKPKTNPNETSQKPKKPTTKAAGETKAKTEPDTDTDISEQNPIR 389

Human   247 -------LVQVKEAE-------RHHS------SPKRELPPGIGD----------------MVELM 275
                   :.|:|..|       .|.|      :.|...|.|:.|                |..|:
  Fly   390 QAQVTPEITQLKNIELINNTKNAHKSALEMRTTMKSSQPNGLDDAPTRMRAPDEMRATTWMTTLV 454

Human   276 G---------------------------------------------------VQD---------- 279
            |                                                   :||
  Fly   455 GSNCHSHSHSHPAVAKSKDPNSDTDSALSSAPPSISPQPPSSGSDSGVIWQTLQDLDKLQKEAEM 519

Human   280 -QHMDERDVRRFQL--------------------KIAELNSVIRKLEDRNTLLADERNELLKRSR 323
             |..:||.....||                    :|.||...|::||:..:.|.||.:||.:::.
  Fly   520 YQKENERLQTEVQLMKQELDAAEKAAISRAKKQAQIGELMQRIKELEEMQSSLEDEASELREQNE 584

Human   324 ETEVQLKPLVEKNKRMNKKNE-------DLL-QSIQRMEEKIKNLTRENVEMKEKLSAQASL--- 377
            ..|.::..|.:.:.:|....|       ||| ||.||:|::.|...::.::..::|.....:
  Fly   585 LLEFRILELEDDSDKMESTCEGHCQSLQDLLEQSAQRLEDRDKRCLQQLLQCVQQLDLDTMMPGD 649

Human   378 -------KRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRH-------RGK 428
                   |||.|.:..|.:....:....|:....|.:  .:.:........||||       :..
  Fly   650 QNRTETPKRHNSTHSHSHSHSHSQSHNHRIVATVQPY--SNCATPTAPPTPSKRHCNQVSSWQSS 712

Human   429 SLKP--------------PKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT 479
            ||..              |..|....|:....|.::.:.|...|        :..|....|....
  Fly   713 SLSESGVFVECDLLSNPNPIGHPHLQFYQERLEQLEGKLLIYES--------SGETQARHLAQRL 769

Human   480 ARE---EADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREAR---TREQLQADLLRCQ-AKIE 537
            .||   |.||:  :|....:.|....|.|:|......:||.:.|   .|.:::.::||.: .::|
  Fly   770 QRELQLEKDLK--ELADRVELLIEQNAQLEEAKCEFEEAENDTRLHLQRNEVELEILRQRNVELE 832

Human   538 DLEKLLVEKGQDSKWVEEKQLLIRTNQDLLE-KIYRLEMEENQLKNEMQDAKDQNE-LLEFRVLE 600
            ..::.|..|.||.:   .:.|::|.:....| ::..|:.|..|.:.|:||.:.... ||.||:|.
  Fly   833 FGKEALGAKYQDCR---AEVLILREDLAAAETQLEHLQAERKQARKELQDLRRSLPLLLIFRLLS 894

Human   601 LEE--RERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNEEQVA 663
            |.:  .|..||..:.::::   .::|::    ||:  :|.:......:.| ||..|...:.|:..
  Fly   895 LAKMGNEESSPGGSPRLSS---GYTSSI----HQD--RDFSAKIQTTEFD-LGQAGFTDSGEERE 949

Human   664 IIQAGTVLALCEKWLKQI-----EGTEAALTQKMLDLEKEKDLFSRQKGYLE-EELDYRKQA-LD 721
            |:.....:......||::     |..|.| ....:|||::         |.| ||....|:| |.
  Fly   950 IVYLKEEVKSLRSQLKELNARHYEAMETA-DSHWVDLEQQ---------YKEREEAQQAKEASLK 1004

Human   722 QAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQ-----AAVEKVRRQILRQSREFDSQI- 780
            |...::||        ..:|..|.|.|.:.:.:..:|.     ..:.|..|.:|.::|.....:
  Fly  1005 QKIAQLQD--------CLREDSRAATEKIQQLEEGELSLKSCLVRMTKEHRDLLTENRTLQCSLE 1061

Human   781 -LRERMELLQQAQQRIRELEDKLEFQKRHLKELEEKFLF 818
             |..:||  ::|:.:: .|.:.||.::|..:.|.:..:|
  Fly  1062 SLMAKME--KEAEHKM-PLTEALENERRKTQALMDDLIF 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JAKMIP1	NP_001092903.1	Mediates association with microtubules	1..365		121/568 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		1/5 (20%)
		Smc	<24..>607	CDD:440809	178/844 (21%)
		JAKMIP_CC3	415..612	CDD:464986	53/228 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..477		4/24 (17%)
Pif1A	NP_001189195.2	JAKMIP_CC3	<516..595	CDD:464986	18/78 (23%)
		Smc	<741..>1156	CDD:440809	91/401 (23%)