DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk3 and Dyrk2

DIOPT Version :9

Sequence 1:	NP_034564.2	Gene:	Hipk3 / 15259	MGIID:	1314882	Length:	1192	Species:	Mus musculus
Sequence 2:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster

Alignment Length:	706	Identity:	190/706 - (26%)
Similarity:	300/706 - (42%)	Gaps:	151/706 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse    46 NGRNFGNSHPSTKGSAFQTKIPFTKPRGHSFSLQAGAIVVKDTAGATKVLAAQAQQAGVEAPRAV 110
            |..|.||.    :||:       ||....|.|..:|.......:|..|.....       .|..:
  Fly   121 NSSNGGNE----RGSS-------TKSNSSSGSGSSGNSASSTGSGELKCNTPM-------TPSEL 167

Mouse   111 V--WRNRLHFLEGPQRCGLKRKSEELENHSGAMQIVDELSILPAMLQTNMGNPV-TVVTATTGSK 172
            |  :||.|..||          .|||       ::..|:.........|...|. |..|...|..
  Fly   168 VKKFRNYLTDLE----------FEEL-------KVYKEVWYFGQHASKNYNKPAPTANTTNLGYD 215

Mouse   173 QNCTSGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQ 237
            .:    .|:|::::|:.:..   .||:|:.:|:|:||||::.....||..|||||::|...:..|
  Fly   216 DD----NGNYKIIEHDHIAF---RYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQ 273

Mouse   238 GQIEVSILARLSTENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRP 301
            ..:|::||..|..::|| .:|.:...:....|.|.|:.||::..|||:.:|:|.::...:.:||.
  Fly   274 AVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRR 338

Mouse   302 VLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYR 366
            ....:...|:.|....:||.|||||||:|..  |....:|||||||:.:|.:.: .||:|||:||
  Fly   339 FCNSIVKCLRLLYKENIIHCDLKPENILLKQ--RGSSSIKVIDFGSSCYVDRKI-YTYIQSRFYR 400

Mouse   367 APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTR 431
            :||:||||.:..|||||||||::|||:.|:||:||..|.:|:..|.:..|||.:.|::|..:...
  Fly   401 SPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRL 465

Mouse   432 FFCRETDMSHSGWRLKTLEEHEAETGMKSKEARKYI--FNSLDDIVHVNTVMDLEGGDLLAEKAD 494
            ||                :..:|...:.:.:.||..  ..||..|:|                ..
  Fly   466 FF----------------DSRDAPRCITNTKGRKRSPGSKSLAHILH----------------CQ 498

Mouse   495 RREFVNLLKKMLLIDADLRITPIETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSPSSCETNN 559
            .|.|::.|::.|..|...|:||.|..:|.|     |.....|.| :||    .:..|.||...|:
  Fly   499 DRYFIDFLQRCLEWDPAERMTPDEAAHHEF-----LQPSASSRH-RSC----RMSSSSSSSGLNS 553

Mouse   560 HSKMSLLRPVA--SNGT-AALAANFTKVGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFHQ 621
            .|:.|.....:  |.|| ..:.|:.|....:.:.|:.|:..|...
  Fly   554 VSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQ-------------------- 598

Mouse   622 TLIICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLS--------QQ----- 673
                 ||:     .:||...|.....|..:....:..::|.:.:|..:.|        ||
  Fly   599 -----PPS-----QSHGHAQSNGHLPDIKLSASDKYNSMQKVAVRSKITSSVSDLESVQQYSLHR 653

Mouse   674 ----TWSGRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMIPHSNHYN 725
                ..||.|..:...|.::..|.       |..|:.|:.. ..:|......||:|
  Fly   654 IYGGVGSGSTHHVSSAATRKHLPG-------TGSGIVGAMS-SKYGSSTLAHNHHN 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk3	NP_034564.2	PKc_like	196..525	CDD:304357	115/331 (35%)
		S_TKc	197..525	CDD:214567	115/330 (35%)
		Interaction with AR. /evidence=ECO:0000250	767..921
		Interaction with FAS. /evidence=ECO:0000269\|PubMed:11034606	775..868
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	799..829
		Required for localization to nuclear speckles. /evidence=ECO:0000250	832..988
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	843..895
		Interaction with UBL1. /evidence=ECO:0000250	847..857
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..943
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..1023
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	125/389 (32%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	116/335 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840