DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hipk3 and mnb

DIOPT Version :9

Sequence 1:NP_034564.2 Gene:Hipk3 / 15259 MGIID:1314882 Length:1192 Species:Mus musculus
Sequence 2:NP_728107.2 Gene:mnb / 32771 FlyBaseID:FBgn0259168 Length:1047 Species:Drosophila melanogaster


Alignment Length:911 Identity:231/911 - (25%)
Similarity:351/911 - (38%) Gaps:229/911 - (25%)


- Green bases have known domain annotations that are detailed below.


Mouse   176 TSGEGD-------------YQLVQHEVLCSMKN------TYEVLDFLGRGTFGQVVKCWKRGTNE 221
            |.|:.|             |....|:.:  :||      .||:...:|:|:||||||.:......
  Fly   265 TQGDDDSSNKKERKLYNDGYDDDNHDYI--IKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQC 327

Mouse   222 IVAIKILKNHPSYARQGQIEVSILARLSTENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDF 285
            .|||||:||...:..|.||||.:|..::..:|: :|..|:....|..|||.|||||:|..||||.
  Fly   328 HVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDL 392

Mouse   286 LKQNKFSPLPLKVIRPVLQQVATALKKLKS--LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSA 348
            |:...|..:.|.:.|...||:.|||..|.:  |.:||.|||||||:|.:|.|.  .:|::||||:
  Fly   393 LRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIVDFGSS 455

Mouse   349 SHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQ 413
            ..:.:.:.. |:|||:||:||::||:.:..|||||||||::.|:..|.||:.|..|.||:..|.:
  Fly   456 CQLGQRIYH-YIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVE 519

Mouse   414 TQGLPGEQLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAETGMKSKEARKYI---FNSLDDIV 475
            ..|:|.:.||:...|:.:||  :..::...:.||           |::..|||.   ...|.||:
  Fly   520 VLGMPPKYLLDQAHKTRKFF--DKIVADGSYVLK-----------KNQNGRKYKPPGSRKLHDIL 571

Mouse   476 HVNTVMDLEGGDLLAEK----ADRREFVNLLKKMLLIDADLRITPIETLNHPFVNMKHLLDFPHS 536
            .|.|  ...||..|.|.    :|..:|.:|:.:||..|...|:||...|.|.|  .|...|    
  Fly   572 GVET--GGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNF--FKRTAD---- 628

Mouse   537 NHVKSCFHIMDICKSPSSCETNNHSKMSLLRPVASNGTAALAANFTK-------VGTLRSQALTT 594
                               |..|.|.........:.|:.:..|..:.       :|...|.:...
  Fly   629 -------------------EATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAV 674

Mouse   595 SAHSVVHHGIPLQAGTAQFGCGDAFHQTLIICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAPA 659
            |:.|.........|.||....|              .|.....|   |.:.:....:||....|.
  Fly   675 SSSSAAAPTAATAAATAAGSSG--------------SGSSVGGG---SSAAQQQQAMPLPLPLPL 722

Mouse   660 VQPLQIRPGVLSQQTWSGRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMIPHSNHY 724
            ..|....||..|    .|:...:|:.:                   ..:..:.::..:...||.:
  Fly   723 PLPPLAGPGGAS----DGQCHGLLMHS-------------------VAANAMNNFSALSLQSNAH 764

Mouse   725 NSVMPPPLLTNQITLSAPQPISVG-IAHVVWPQPATTKKNKLCQNRSNSLQNTNIPHSAFISPKI 788
                |||.|.|    |.....|:| :.|:   .|.:|.    |.|.:::..|.|..||......:
  Fly   765 ----PPPSLAN----SHHSTNSLGSLNHI---SPGSTG----CHNNNSNSSNNNTRHSRLYGSNM 814

Mouse   789 I-------SGKEVEEVSCVDTQDNHTS-------------------EGEA--------------- 812
            :       ||          :.:||.|                   .|..               
  Fly   815 VNMVGHHNSG----------SSNNHNSISYPHAMECDPPQMPPPPPNGHGRMRVPAIMQLQPNSY 869

Mouse   813 --------GTCREASVRQDSSVSDKQRQTIIIADSPSPAVSVITISSDSDDEETSPRPSLRECKG 869
                    |....:||...::.:......:::.||     |||:.|: :...:....|.      
  Fly   870 APNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDS-----SVISASA-AGGGQGGGNPG------ 922

Mouse   870 SLDCEACQSTLNIDRMCSL--SSPDSTLSTSSSGQSSPSPCKRPNSMSDDEQESGCETVDGSPTS 932
                   |:.:.......|  |.|..||..::.|..|..|...|..||...|     ....|.:|
  Fly   923 -------QNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQ-----LPPSSSSS 975

Mouse   933 DSSGHDSPFAENSFVEDAHQNTELGTCAGPEAKPAVGTAVEPPVGRESGLSVDEHMANTDSTCQP 997
            .|||..|..:....|....|...:   .||.|:  ||  :...||..|..|.....::..|:..|
  Fly   976 VSSGSASVGSGGVGVGVVGQRRHI---TGPAAQ--VG--ISQSVGSGSSGSATGASSSDASSSSP 1033

Mouse   998 L 998
            :
  Fly  1034 M 1034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hipk3NP_034564.2 PKc_like 196..525 CDD:304357 129/338 (38%)
S_TKc 197..525 CDD:214567 129/337 (38%)
Interaction with AR. /evidence=ECO:0000250 767..921 34/204 (17%)
Interaction with FAS. /evidence=ECO:0000269|PubMed:11034606 775..868 20/141 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 799..829 7/71 (10%)
Required for localization to nuclear speckles. /evidence=ECO:0000250 832..988 37/157 (24%)
SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250 843..895 9/53 (17%)
Interaction with UBL1. /evidence=ECO:0000250 847..857 2/9 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 889..943 17/53 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 956..1023 11/43 (26%)
mnbNP_728107.2 PKc_DYRK1 289..628 CDD:271128 134/360 (37%)
S_TKc 303..623 CDD:214567 130/339 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0667
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R968
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.840

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