DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hipk2 and Hipk

DIOPT Version :10

Sequence 1:NP_034563.2 Gene:Hipk2 / 15258 MGIID:1314872 Length:1196 Species:Mus musculus
Sequence 2:NP_001369036.1 Gene:Hipk / 38070 FlyBaseID:FBgn0035142 Length:1409 Species:Drosophila melanogaster


Alignment Length:1274 Identity:487/1274 - (38%)
Similarity:628/1274 - (49%) Gaps:367/1274 - (28%)


- Green bases have known domain annotations that are detailed below.


Mouse    92 HIVVTSASSTSVTGQVLGGPHNLMRRST---VSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPM 153
            ||:...|:|.| |..|.....:..:|.|   ...:|:|             |:|       |.|.
  Fly    70 HILRQPATSAS-TSSVAAAATSKRKRQTDCDCGCVDSY-------------NSS-------HGPP 113

Mouse   154 IQNNASGA-----------------------TVATATTSTAT----------SKNSGSNSEGDYQ 185
            :|.::|.|                       ::.||.|..||          ||.|.|.::||||
  Fly   114 VQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQ 178

Mouse   186 LVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARL 250
            |||||||.|::..|||||||||||||||||||||||:|||||||||||||||||||||||||:||
  Fly   179 LVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRL 243

Mouse   251 STESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKL 315
            |.|:||::|||||:|||||||||||||||||||||||||||||||||||||||:|:||.|||:||
  Fly   244 SQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKL 308

Mouse   316 KSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCE 380
            |.||||||||||||||||||.|||||||||||||||||||.||:|||||||||||||||||||||
  Fly   309 KQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCE 373

Mouse   381 AIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPL 445
            ||||||||||:||||||||||||:||:|||||||||||||.|::|::.:||::||.||.||.||.
  Fly   374 AIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPF 438

Mouse   446 WRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTI 510
            |||||.::|||||..|||||||||||||||:.|||:.|||||..:|.||.||||||||||:||||
  Fly   439 WRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTI 503

Mouse   511 DADKRVTPIETLNHPFVTMTHLLDFPHSAHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPS 575
            |.::|:||.|.|||.|..:|||:|:.:..:||:..|.||:|:|  ..:.||..:.| .:|:..||
  Fly   504 DQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRR--GDFHTVQPAST-LVTNFVPS 565

Mouse   576 TSTNLTMTFNNQLTT-----VHNQAPTTSSATLSLANPEVSILNYQSALYQ-PSAASMAAVAPRS 634
            ::.|:|.|.|||||:     |.:..|                |.|: .||| .:..|:|...|::
  Fly   566 STENMTFTINNQLTSQVQRLVRDGRP----------------LAYE-GLYQIYNGRSVARQYPQT 613

Mouse   635 MPLQTGTAQICARPDPFQQAL---IVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQ 696
                        |.|.||..|   |:|||.:|.: .||:||.           :|..|....|||
  Fly   614 ------------RTDSFQHQLVSNILCPPSYQTM-PSPTKHV-----------VVGSATMQPPLQ 654

Mouse   697 IQPG--------------------LLAQQ------AWPGGAQQILLPPAWQQLTGVATHTSVQHA 735
            :.|.                    ||..:      |||...:|:.|.|:|.|       .:..|:
  Fly   655 VPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQ-------QAPAHS 712

Mouse   736 AVIPET-MAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTT 799
            .::..| :...:::        :..|             |:.||.........||.:.:..:...
  Fly   713 LIVDSTPLFNVEEI--------YPKH-------------HLNLPRNDLKKESPAHHIAKGNSYRV 756

Mouse   800 SSRKSKQHQSSVRNVSTCEVTSSQAISSPQRSKRVKENTPP------RCAMVHSSPACSTSVTCG 858
            ...:.|:||.                .||.: |||||::||      |.|  |.||.......|.
  Fly   757 PRHEKKEHQQ----------------LSPVK-KRVKESSPPHQQRYQRAA--HVSPQYHAHHNCN 802

Mouse   859 WGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHD 923
            :|:.:..:.....    |:..:.:.:.:::..||.:....   |.|.:               |.
  Fly   803 YGNGSGYSASAGS----VVASSAASSSNIVNGSSSSSHHH---HVPVA---------------HA 845

Mouse   924 SPYSDSSSNTSPYSVQQRTGHNGTNTLDTKGG--------------------------------- 955
            .|||.||            ||:..:..:..||                                 
  Fly   846 QPYSSSS------------GHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHV 898

Mouse   956 ----LENHCTGNPRTII----------------VPPLKTQASEVLVECDSLGPAISASHHSSSFK 1000
                :..|.|.:|..:|                ||.||.:|                  |:.|  
  Fly   899 KQPTITIHDTPSPTAVITISDSEDEGGEAGGAQVPVLKQRA------------------HAQS-- 943

Mouse  1001 SKSSSTVTSTSG----HS-SGSSSGAIAYRQQRPGPHFQQQQPLNL-------SQAQQH-MAADR 1052
                    .|||    |: |.|.|.:.|::|..|.|..||||.:|.       ::.:.| .||..
  Fly   944 --------QTSGSLLQHAPSSSCSRSSAHQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAA 1000

Mouse  1053 TGS-----HRRQQAYITPTMAQAPYTFPHNSPSHGTVHPH---------------LAAA------ 1091
            .||     |::||....|...|.....|...|......|.               ||.|      
  Fly  1001 VGSPKHHHHQQQQQPAPPPQQQQQQYQPQPPPQQVLPQPQPSIKYEPGQSQKKRILAMAQSECGY 1065

Mouse  1092 -AHLPTQPHLYTYTAPTALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQ-----VPVSMGPRV 1150
             ..:|:||           .|:.::.|:...|..|....::.|.|...:..     .|.|.|..|
  Fly  1066 QPQVPSQP-----------SSSASLPHIPTKQEPAEFYPEYAAAPPQQLDTKRSSWAPTSSGSGV 1119

Mouse  1151 LPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAK 1189
            ...|..||.:.....|..:|::.|.|.      ||:.:|
  Fly  1120 SALPLAHPKREAPSVAPISYVAPSVAP------PLAHSK 1152

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hipk2NP_034563.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..69
Transcriptional corepression 97..230 66/168 (39%)
STKc_HIPK2 183..537 CDD:271129 290/353 (82%)
Interaction with DAXX. /evidence=ECO:0000250 189..520 275/330 (83%)
Interaction with SKI and SMAD1. /evidence=ECO:0000250 539..844 82/346 (24%)
Interaction with DAZAP2. /evidence=ECO:0000250|UniProtKB:Q9H2X6 600..800 46/230 (20%)
Interaction with POU4F1. /evidence=ECO:0000269|PubMed:15492043 752..897 28/150 (19%)
Interaction with CTBP1. /evidence=ECO:0000269|PubMed:14567915 774..876 24/107 (22%)
Interaction with HMGA1. /evidence=ECO:0000269|PubMed:11593421 787..897 24/115 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 792..847 14/60 (23%)
Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250 802..805 0/2 (0%)
Nuclear localization signal 2 (NLS2). /evidence=ECO:0000250 832..835 2/2 (100%)
Interaction with TP53 and TP73. /evidence=ECO:0000269|PubMed:11780126 839..934 20/100 (20%)
Localization to nuclear speckles 873..980 24/159 (15%)
Required for localization to nuclear speckles. /evidence=ECO:0000250 873..980 24/159 (15%)
Interaction with UBE2I. /evidence=ECO:0000269|PubMed:10535925 873..907 5/33 (15%)
SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250 884..908 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..963 16/108 (15%)
Interaction with AXIN1. /evidence=ECO:0000269|PubMed:15526030 935..1050 32/180 (18%)
Autoinhibitory domain (AID). /evidence=ECO:0000250 984..1196 57/251 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 991..1058 24/84 (29%)
HipkNP_001369036.1 STKc_HIPK 192..520 CDD:271113 274/327 (84%)
PHA03378 <1080..1327 CDD:223065 19/79 (24%)
Blue background indicates that the domain is not in the aligned region.

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