DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hipk2 and CG7028

DIOPT Version :9

Sequence 1:	NP_034563.2	Gene:	Hipk2 / 15258	MGIID:	1314872	Length:	1196	Species:	Mus musculus
Sequence 2:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	520	Identity:	150/520 - (28%)
Similarity:	235/520 - (45%)	Gaps:	108/520 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse    42 TGYGS---HSKVYSQSKNIPPSQPAS------TTVSTSLPIPNP---SLPYEQTIIFPGSTGHIV 94
            ||..|   |:.|..:|::  .||.:|      .|.|.::|.|||   .:|.::.
  Fly   463 TGQESPAPHNSVSYESRS--TSQGSSQRERPLRTPSPTMPCPNPLISEIPKDRE----------- 514

Mouse    95 VTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQK-CGLKRKSEEIEN------TSSVQIIEEHPP 152
             ...:|||                        || |..|.|..|.:.      .|:..:..:..|
  Fly   515 -DMDNSTS------------------------QKTCSAKEKRNEWDMFADQDVDSNFDVSRKISP 554

Mouse   153 --MIQNNASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVK 215
              ::||.......|..        ::..::||.|::...|||   .|.|.|..:.|:|.|..||
  Fly   555 NTIVQNKHQHENPALT--------DNWDDAEGYYRVRIGEVL---DNRYLVNGYTGQGVFSNVV- 607

Mouse   216 CWKRGTNEI-----VAIKILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTC 274
               ||.::.     |||||::|:....:.|..|:.||.:|:....:| ::.:|.|..|.||.|.|
  Fly   608 ---RGRDQARGQANVAIKIIRNNEIMHKTGLRELEILKKLNDADPEDRFHCLRLYRHFFHKQHLC 669

Mouse   275 LVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQ 338
            :|||.|..||.:.||: .|...|.:|.:|...||:..||..||..|::|||:||:||::   :..
  Fly   670 MVFEPLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILV---NEN 731

Mouse   339 PYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPG 403
            ...:|:.||||||.:|....:.||.||:||:||||||:|:...||.||.||.|.||:.|..|:.|
  Fly   732 NLILKLCDFGSASAISDNEITPYLVSRFYRSPEIILGIPYDYGIDTWSAGCTIYELYTGKILFSG 796

Mouse   404 ASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKY 468
            .|....:::....:|.....::..|....:.|::..:..|          ||.:   |..|..|.
  Fly   797 KSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFDQSCNFLY----------HEID---KLTEREKI 848

Mouse   469 IFNCLDDMAQV----NMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRVTPIETLNHPFV 527
            :.     |..|    ::..:|.....|.:...|:  :..|||:.|..:|..||::..:.|.|||:
  Fly   849 VV-----MPVVKPSRSLQQELIADQNLPDDQHRKVTQLKDLLENMFALDPAKRISLNQALVHPFI 908

Mouse 528 527
Fly 909 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hipk2	NP_034563.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..69		6/24 (25%)
		Transcriptional corepression	97..230		34/146 (23%)
		STKc_HIPK2	183..537	CDD:271129	118/358 (33%)
		Interaction with DAXX. /evidence=ECO:0000250	189..520		113/343 (33%)
		S_TKc	199..527	CDD:214567	112/340 (33%)
		Interaction with SKI and SMAD1. /evidence=ECO:0000250	539..844
		Interaction with POU4F1. /evidence=ECO:0000269\|PubMed:15492043	752..897
		Interaction with CTBP1. /evidence=ECO:0000269\|PubMed:14567915	774..876
		Interaction with HMGA1. /evidence=ECO:0000269\|PubMed:11593421	787..897
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	792..847
		Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250	802..805
		Nuclear localization signal 2 (NLS2). /evidence=ECO:0000250	832..835
		Interaction with TP53 and TP73. /evidence=ECO:0000269\|PubMed:11780126	839..934
		Localization to nuclear speckles	873..980
		Required for localization to nuclear speckles. /evidence=ECO:0000250	873..980
		Interaction with UBE2I. /evidence=ECO:0000269\|PubMed:10535925	873..907
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	884..908
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..963
		Interaction with AXIN1. /evidence=ECO:0000269\|PubMed:15526030	935..1050
		Autoinhibitory domain (AID). /evidence=ECO:0000250	984..1196
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	991..1058
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	112/341 (33%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	110/333 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810