Protein Alignment Hipk1 and Dyrk2

DIOPT Version :9

• Sequence 1: NP_001288233.1
• Gene: Hipk1 / 15257
• MGIID: 1314873
• Length: 1210
• Species: Mus musculus
• Sequence 2: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Alignment Length: 512
• Identity: 152/512 - (29%)
• Similarity: 258/512 - (50%)
• Gaps: 60/512 - (11%)

Mouse    87 TAADSSGSAATATFQSS-QTLTHRSNVSLLEPYQKCGLKRKSEEVESNGSVQIIEEHPPLMLQNR 150
            :.:.|||::|::|.... :..|..:...|::.::......:.||::....|....:|..   :|.
  Fly   139 SGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHAS---KNY 200

Mouse   151 TVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEI 215
            ......|.||.:    ......|:|::::|:   .:...||:||.:|:|:||||.:.....|...
  Fly   201 NKPAPTANTTNL----GYDDDNGNYKIIEHD---HIAFRYEILEVIGKGSFGQVIRALDHKTNTH 258

Mouse   216 VAIKILKNHPSYARQGQIEVSILSRLSSENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFL 279
            |||||::|...:..|..:|::||..|..::|| .:|.:...:....:.|.|:.||::..|||:.:
  Fly   259 VAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELI 323

Mouse   280 KQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 344
            |:|.::...:..||.....:...|..|....:||.|||||||:|..  |....:|||||||:.:|
  Fly   324 KKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQ--RGSSSIKVIDFGSSCYV 386

Mouse   345 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQG 409
            .:.: .||:|||:||:||:||||.:..|||||||||::|||:.|:||:||.:|.:|:..|.:..|
  Fly   387 DRKI-YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLG 450

Mouse   410 LPAEYLLSAGTKTTRFF-NRD-PNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNM 472
            ||.:.|:|...:...|| :|| |..      :...:..:...|.||   ..:|.:|.|
  Fly   451 LPPKVLISVARRRRLFFDSRDAPRC------ITNTKGRKRSPGSKS---LAHILHCQD------- 499

Mouse   473 STDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMSHLLDFPHSSHVKSCFQ 537
                            |.:||.|::.|..|..:|:||.:..:|:|:..|      .||..:||..
  Fly   500 ----------------RYFIDFLQRCLEWDPAERMTPDEAAHHEFLQPS------ASSRHRSCRM 542

Mouse   538 NMEICKRRVHMYDTVSQIKSPFT-THVAPNTSTNLTMSFSNQLNTVHNQASVLASSS 593
            :.......:   ::|||..|.:: :.::|.|:..:..|.:: ...|||.|....:.|
  Fly   543 SSSSSSSGL---NSVSQKSSCYSFSEISPGTNGPVVASITS-TTAVHNAAIATTTKS 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk1	NP_001288233.1	STKc_HIPK1	174..528	CDD:271130	120/356 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	835..856
		Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250	844..847
		Interaction with TP53. /evidence=ECO:0000269|PubMed:12702766	885..1093
		Required for localization to nuclear speckles. /evidence=ECO:0000250	891..998
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	902..926
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	938..981
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1046..1069
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1084..1104
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	125/387 (32%)
		S_TKc	233..529	CDD:214567	116/330 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840