DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CXADR and tutl

DIOPT Version :9

Sequence 1:NP_001329.1 Gene:CXADR / 1525 HGNCID:2559 Length:365 Species:Homo sapiens
Sequence 2:NP_001303307.1 Gene:tutl / 46015 FlyBaseID:FBgn0010473 Length:1536 Species:Drosophila melanogaster


Alignment Length:377 Identity:90/377 - (23%)
Similarity:145/377 - (38%) Gaps:83/377 - (22%)


- Green bases have known domain annotations that are detailed below.


Human     4 LLCFVLLCGVVDFARSLSI-TTPEEM--IEKAKGETAYLPCKFTLSPEDQGPLDIEWLISPADNQ 65
            :|.|||:..:...|::... ..||:.  |....||.....|......:...|..::|      ::
  Fly   110 VLQFVLVSLLALLAKNAQAHNIPEDAVHITAILGEGVIFNCHVEFPNDHPVPYVLQW------DK 168

Human    66 KVDQV---IILYSGDKIYDDYYPD-----LKGRVHFTSNDLKSGDASINVTNLQLSDIGTYQCKV 122
            ||.:.   :.:|    |:.:.||:     .||||...|.|...|.||:|:||::.||.|.|:|||
  Fly   169 KVSETGSDLPIY----IWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKV 229

Human   123 ---KKAPGVANKK---IHLVVLVKPSGARCYVDGSE----EIGSDFKIKCEPKEGSLPLQYEWQK 177
               .:.| ..:|.   .||.|...|   |..|...:    .:|....:.|: .:|:...:..|.|
  Fly   230 VFLNRDP-KQHKNGTWFHLDVHAPP---RFSVTPEDIIYVNLGDSIILNCQ-ADGTPTPEILWYK 289

Human   178 LSDSQKM---PTSWLAEMTSSVISVKNASSEYSGTYSCTVRNRVGSDQCLLRLNV-------VPP 232
              |:..:   ||..:.. ..:.:.:.....|..|.|:|..||..|......|:.:       |||
  Fly   290 --DANPVDPSPTVGIFN-DGTELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVPP 351

Human   233 SNKAGLIAGAIIGTLLALALIGLIIFCCRKKRREEKYEKEV-----HHDIRED----VPPPKSRT 288
            :|:..|....:|.:..|.|:.|.:..   :..||....:||     ...||:|    :.|.|...
  Fly   352 TNQTKLEGEKVIFSCEAKAMPGNVTV---RWYREGSPVREVAALETRVTIRKDGSLIINPIKPDD 413

Human   289 STARSYIGSNHSSLGSMSPSNMEGYSKTQYNQVPSEDFERTPQSPTLPPAKV 340
            |  ..|:....:.:|  .|.:...|...:|                  ||||
  Fly   414 S--GQYLCEVTNGIG--DPQSASAYLSVEY------------------PAKV 443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CXADRNP_001329.1 IgV_CAR_like 20..136 CDD:409552 36/132 (27%)
Ig strand B 37..41 CDD:409552 0/3 (0%)
Ig strand C 54..58 CDD:409552 0/3 (0%)
Ig strand E 103..107 CDD:409552 2/3 (67%)
Ig strand F 117..122 CDD:409552 2/4 (50%)
Ig strand G 130..133 CDD:409552 1/5 (20%)
IG 155..229 CDD:214652 16/76 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 269..343 17/81 (21%)
PDZ-binding 360..365
tutlNP_001303307.1 V-set 137..250 CDD:284989 35/123 (28%)
IG_like 137..229 CDD:214653 29/101 (29%)
I-set 253..341 CDD:254352 19/94 (20%)
IGc2 268..331 CDD:197706 14/66 (21%)
I-set 346..437 CDD:254352 23/97 (24%)
Ig 349..437 CDD:299845 23/94 (24%)
Ig 459..530 CDD:299845
IG_like 549..628 CDD:214653
IGc2 551..617 CDD:197706
FN3 633..725 CDD:238020
FN3 786..874 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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