DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CXADR and CG33543

DIOPT Version :9

Sequence 1:	NP_001329.1	Gene:	CXADR / 1525	HGNCID:	2559	Length:	365	Species:	Homo sapiens
Sequence 2:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster

Alignment Length:	255	Identity:	53/255 - (20%)
Similarity:	92/255 - (36%)	Gaps:	83/255 - (32%)

- Green bases have known domain annotations that are detailed below.

Human     4 LLCFVLLCGVVDFARSLSITTPEEMIEKAKGETAYLPCKFTLSPEDQGPLDIEWLISPADNQKVD 68
            |..|.||..     :.:|....|::....:|..|.:.|            .:|.:.:|
  Fly   141 LASFELLVN-----QKISFGKTEQVQSVREGRDAMVNC------------FVEGMPAP------- 181

Human    69 QVIILYSGDKIYDDYYPDLKGRVHFTSNDLKSGDASINVTNLQLSDIGTYQCKVKKAPGVANKKI 133
            :|..||:|     :|...:....|   |.|.:|   :.:.|:..:|.|.|.|:..:
  Fly   182 EVSWLYNG-----EYINTVNSTKH---NRLSNG---LYIRNVSQADAGEYTCRAMR--------- 226

Human   134 HLVVLVKPSGARCYVDGSEEIGSDFKIKCEPK---EGSLPLQYEW----QKLS-DSQKMPT---S 187
                 :.|:     ...|::|....:|:.:|.   ..:||:||.:    ..|| |:...|.   :
  Fly   227 -----ITPT-----FSDSDQITILLRIQHKPHWFFNETLPVQYAYVGGAVNLSCDAMGEPPPSFT 281

Human   188 WLAEMTSSV----------------ISVKNASSEYSGTYSCTVRNRVGSDQCLLRLNVVP 231
            ||......|                :.:||||.  .|.|.|.|.|.:|..:.:::|...|
  Fly   282 WLHNNKGIVGFNHRIFVADYGATLQLQMKNASQ--FGDYKCKVANPLGMLERVIKLRPGP 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CXADR	NP_001329.1	IgV_CAR_like	20..136	CDD:409552	21/115 (18%)
		Ig strand B	37..41	CDD:409552	1/3 (33%)
		Ig strand C	54..58	CDD:409552	1/3 (33%)
		Ig strand E	103..107	CDD:409552	0/3 (0%)
		Ig strand F	117..122	CDD:409552	2/4 (50%)
		Ig strand G	130..133	CDD:409552	0/2 (0%)
		IG	155..229	CDD:214652	24/100 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..343
		PDZ-binding	360..365
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	19/88 (22%)
		IG_like	256..336	CDD:214653	20/81 (25%)
		IGc2	263..327	CDD:197706	16/65 (25%)
		FN3	341..445	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910