DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IGSF11 and tutl

DIOPT Version :9

Sequence 1:	NP_001340247.1	Gene:	IGSF11 / 152404	HGNCID:	16669	Length:	481	Species:	Homo sapiens
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	101/494 - (20%)
Similarity:	155/494 - (31%)	Gaps:	152/494 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    12 LLLSLHDPERRGQHTSGPAGGRGVIQDMYSQLAVGKKTERDRHVGRSLYWGPSCYPSVAASLEVS 76
            |:::...|:..||:......|.|..|                        ..|.|.||....:|:
  Fly   404 LIINPIKPDDSGQYLCEVTNGIGDPQ------------------------SASAYLSVEYPAKVT 444

Human    77 ESPGSIQVARGQPAVLPCTFTTSAALINLNVIWMVTPLSNANQPEQ----VILYQGGQMFDGAPR 137
            .:|....:......|:.|...:|..|  ..|.|  |......:|.|    |::..|..:|.....
  Fly   445 FTPTVQYLPFRLAGVVQCYIKSSPQL--QYVTW--TKDKRLLEPYQMKDIVVMANGSLLFTRVNE 505

Human   138 FHGRVGFTGTMPATNVSIFINNTQLSDTGTYQCLVNNLPDIGGRNIGVTGLTVLVPPS---APHC 199
            .|                         .|.|.|...|.....|.: ||..:.|..||:   .|..
  Fly   506 EH-------------------------QGQYACTPYNAQGTAGAS-GVMDVLVRKPPAFTVEPET 544

Human   200 QIQGSQDIGSDVILLCSS--EEGIPRPTYLWEKLD---------NTLKLPPTATQDQVQGTVTIR 253
            ..|  :.:|..|.:.|.:  .||..|||..|::.:         |.:|:.        .|.:||.
  Fly   545 LYQ--RKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKIS--------GGNITIE 599

Human   254 NISALSSGLYQCVASNAIGTSTCLLDLQVISPQPRNIGLIAGAIGTGAVIIIFCIALILGAFFYW 318
            |:.....|.||||.||.:.|...:..|.:...||.....|.|.....::.:.:......|
  Fly   600 NLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQPHAPYNITGKATESSITLQWLPGYSGG----- 659

Human   319 RSKNKEEE----EEEIPNEIREDDLPPKCSSAKAFHTEISSSDNNTLTSSNAYNSRYWSNN---- 375
             |:.|::.    .|...|:.:...:.|..|      |:::.   |.|.|...|..:....|
  Fly   660 -SEYKQDYTIWFREAGVNDWQTISVTPSGS------TQVTI---NGLASGTTYEFQVVGRNVLGD 714

Human   376 ---------------PKVHRNTESVSHFSDLGQSFSFHSGNANIPSIYANGTHLVPGQHKTLVV- 424
                           |...||.::.:...|     ||.              .|:|.:...|..
  Fly   715 GMMSKVMTVRTLEDAPAAPRNVKAATQPPD-----SFF--------------QLMPDEADLLAYF 760

Human   425 -----TANRGS---SPQVMSRSNGSVSRKPRPPHTHSYT 455
                 |.:||:   ||..: |..|.   ||.||...|.|
  Fly   761 DIYFHTDSRGTLVYSPPKL-RVKGP---KPGPPRNVSVT 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF11	NP_001340247.1	V-set	77..191	CDD:311561	21/117 (18%)
IGSF11	NP_001340247.1	Ig_3	208..269	CDD:316449	20/71 (28%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989
		IG_like	137..229	CDD:214653
		I-set	253..341	CDD:254352
		IGc2	268..331	CDD:197706
		I-set	346..437	CDD:254352	9/56 (16%)
		Ig	349..437	CDD:299845	9/56 (16%)
		Ig	459..530	CDD:299845	20/100 (20%)
		IG_like	549..628	CDD:214653	24/86 (28%)
		IGc2	551..617	CDD:197706	22/73 (30%)
		FN3	633..725	CDD:238020	16/106 (15%)
		FN3	786..874	CDD:238020	5/10 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910