DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IGSF11 and DIP-beta

DIOPT Version :9

Sequence 1:	NP_001340247.1	Gene:	IGSF11 / 152404	HGNCID:	16669	Length:	481	Species:	Homo sapiens
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	178	Identity:	45/178 - (25%)
Similarity:	74/178 - (41%)	Gaps:	15/178 - (8%)

- Green bases have known domain annotations that are detailed below.

Human   157 INNTQLSDTGTYQCLVNNLPDIGGRNIGVTGLTVLVPPSAPHCQIQGSQDI--GSDVILLCSSEE 219
            |...::.|.|.|.|.||..|    ..:....|.|::||...:.:..|...:  |....|:|.: .
  Fly   178 IRGVKMEDAGKYMCQVNTDP----MKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRA-R 237

Human   220 GIPRPTYLWEKLDNTLKLPPTATQDQ-----VQG-TVTIRNISALSSGLYQCVASNAI-GTSTCL 277
            |.|:|...|.:.|....:....:..:     |:| .:|:..|:....|.|.|:|||.: .|.:..
  Fly   238 GHPKPKITWRREDGREIIARNGSHQKTKAQSVEGEMLTLSKITRSEMGAYMCIASNGVPPTVSKR 302

Human   278 LDLQV-ISPQPRNIGLIAGAIGTGAVIIIFCIALILGAFFYWRSKNKE 324
            :.||| ..|..:....:.||.....|.:|..:.....|..||:.:|.|
  Fly   303 MKLQVHFHPLVQVPNQLVGAPVLTDVTLICNVEASPKAINYWQRENGE 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF11	NP_001340247.1	V-set	77..191	CDD:311561	9/33 (27%)
IGSF11	NP_001340247.1	Ig_3	208..269	CDD:316449	16/66 (24%)
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	10/34 (29%)
		ig	102..195	CDD:278476	6/16 (38%)
		IG_like	219..307	CDD:214653	21/88 (24%)
		Ig	221..307	CDD:299845	20/86 (23%)
		Ig	311..404	CDD:299845	10/40 (25%)
		IG_like	327..405	CDD:214653	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910