DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IGSF11 and sma-10

DIOPT Version :9

Sequence 1:	NP_001340247.1	Gene:	IGSF11 / 152404	HGNCID:	16669	Length:	481	Species:	Homo sapiens
Sequence 2:	NP_499896.1	Gene:	sma-10 / 176849	WormBaseID:	WBGene00020649	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	457	Identity:	93/457 - (20%)
Similarity:	146/457 - (31%)	Gaps:	144/457 - (31%)

- Green bases have known domain annotations that are detailed below.

Human     7 PLAPLLLLSLHDPERRGQHTSGPAGGRGVIQDMYSQLAVGKKTERDRHVGRSLYWGPSCYPSVAA 71
            |||.|.:::: |......|...|. .:.|.|.:.....:|:|.....:|
Worm   482 PLADLYVVAI-DTANLTCHNDSPR-AKIVRQPVEVSTLIGEKARFTCNV---------------- 528

Human    72 SLEVSESPGSIQ---VARGQPAVLPCTFTTSAALINLNVIWMVTPLSNANQPEQVILYQGGQMFD 133
               ...||.||:   :..|||.||   ...||..:::|    .|.:.|....|:.:
Worm   529 ---YGASPLSIEWRVMENGQPRVL---VQDSATFLSIN----RTAVVNGTFDEREL--------- 574

Human   134 GAPRFHGRVGFTGTMPATNVSIFINNTQLSDTGTYQCLVNNLPDIGGRNIGVTGLTVLVPPSAPH 198
                             ....:.::|..::|...|||:..|  ..|........|.|...|...:
Worm   575 -----------------AAAELLLDNVAMTDNSEYQCVARN--RFGSDFSTHVKLQVYQAPKFTY 620

Human   199 CQIQGSQDIGSDVILLCSSEEGIPRPTYLW--EKLD----NTLKLPPTATQDQVQGTVTIRNISA 257
            ........:|.....||:: .|.|||...|  |::.    ...:|..|...|.:.    |.|::.
Worm   621 TPEDMPLLVGQTAKFLCAA-TGTPRPEIKWAFEQIPFPAAEARRLYVTPNDDHIY----IMNVTK 680

Human   258 LSSGLYQCVASNAIGTSTCLLDLQVISPQPRNIGLIAGAIGTGAVIIIFCIALILGAFFYWRSKN 322
            ...|.|.|.|:|                       :||.....|.:|:|      ..||::
Worm   681 EDQGAYTCHATN-----------------------VAGQTQASANLIVF------ENFFHY---- 712

Human   323 KEEEEEEIPNEIRE-DDLPPKCS----SAK------------AFHTEISSSDNN--------TLT 362
             .|..:..|..|:: |.|...||    |::            .|..:...|||:        |.:
Worm   713 -PESPDLSPMLIKKRDALKIDCSCDLISSRQRMVWKRQQQVILFLKKAKFSDNDQILTLTQTTFS 776

Human   363 SSNAYNSRYWSNNP---------KVHRNTESVSHFSDLGQSFSFHSGNA-----NIPSIYANGTH 413
            .|..|:...|.::.         ||....|.||..:.|.|........|     ||.|. .||.:
Worm   777 DSGEYSCELWVDDTILMRKITMVKVVNEDEFVSSEATLTQRVQRIRAMASKLVDNIKST-GNGIY 840

Human   414 LV 415
            |:
Worm   841 LM 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF11	NP_001340247.1	V-set	77..191	CDD:311561	23/116 (20%)
IGSF11	NP_001340247.1	Ig_3	208..269	CDD:316449	18/66 (27%)
sma-10	NP_499896.1	LRRNT	29..54	CDD:214470
		leucine-rich repeat	55..77	CDD:275380
		LRR_8	78..135	CDD:290566
		LRR_4	78..116	CDD:289563
		leucine-rich repeat	78..101	CDD:275380
		LRR_RI	100..303	CDD:238064
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..172	CDD:275380
		LRR_8	172..231	CDD:290566
		leucine-rich repeat	173..196	CDD:275380
		leucine-rich repeat	197..220	CDD:275380
		leucine-rich repeat	221..244	CDD:275380
		LRR_8	243..303	CDD:290566
		leucine-rich repeat	245..268	CDD:275380
		LRR_RI	269..453	CDD:238064
		leucine-rich repeat	269..292	CDD:275380
		leucine-rich repeat	293..316	CDD:275380
		LRR_8	315..373	CDD:290566
		leucine-rich repeat	317..340	CDD:275380
		leucine-rich repeat	341..364	CDD:275380
		leucine-rich repeat	365..392	CDD:275380
		LRR_8	393..450	CDD:290566
		leucine-rich repeat	393..416	CDD:275380
		leucine-rich repeat	417..438	CDD:275380
		I-set	506..612	CDD:254352	28/159 (18%)
		Ig	522..606	CDD:143165	23/137 (17%)
		I-set	616..705	CDD:254352	23/116 (20%)
		Ig	633..705	CDD:299845	21/99 (21%)
		Ig	716..786	CDD:299845	14/69 (20%)
		IG	719..788	CDD:214652	15/68 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910