DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNTN4 and Cont

DIOPT Version :9

Sequence 1:	NP_001193884.1	Gene:	CNTN4 / 152330	HGNCID:	2174	Length:	1026	Species:	Homo sapiens
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	1051	Identity:	318/1051 - (30%)
Similarity:	487/1051 - (46%)	Gaps:	81/1051 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    25 GPIFIQEPSPVMFPLDSEE--KKVKLNCEVKGNPKPHIRW--------KLNGTDVDTGMDFRYSV 79
            ||.|:::|:...|.::...  ..|.|:|...|.|.|...|        :|....:|.....||::
  Fly   361 GPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTI 425

Human    80 VEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLC 144
            ..|:|:|..|.:..|.|.|.|.|.|.||.|.|..|.|.|.::..|..: ||..:.....|..:.|
  Fly   426 SGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLK-RSAETSEMNWGKSIFC 489

Human   145 GPPPHSGELSYAWIFNEYPSY--QDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLG 207
            .||.|..::.|.|..:.:|::  :|.|.|||:: |.||.:.:|..|..||:|.|...|::....|
  Fly   490 DPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRD-GALYFSFIETVDRANYSCTVQTLVSDTGRNG 553

Human   208 PPTPL-ILRNDG----VMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPI 267
            |..|| :..|..    :.....||:   ||| .|.| |..::|||.|.|.|:|:..|.| .|.|:
  Fly   554 PFFPLRVTPNSNYQALIFANTFPKV---FPE-APVA-GDEIRLECMAFGYPIPSYNWTR-QGLPL 612

Human   268 ARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEEN 332
            .|.|.......:|.|.|....|.|.|.|...|.|...:....:....:|.:...:.|:......:
  Fly   613 QRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSD 677

Human   333 VFWECKANGRPKPTYKWLKNGEPL----LTRDRIQIEQGTLNITIVNL-SDAGMYQCLAENKHGV 392
            |.:.|:|...|...|.|.||.|.|    :.|||..|:...|.|..:.. .|..||||.|:|:...
  Fly   678 VTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKT 742

Human   393 IFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITIS 457
            .||:|:|.|:::.|.|.:..|:........|...|.|.|:|:|:|.:.|||...::.......|.
  Fly   743 SFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGGHRRIL 807

Human   458 EDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTR-VMVPPSSMDVTVGESIVLPCQV 521
            ..|.|.|...::.|.|.|||||:|..||..|...::|....| :..||..:.....:.|.|.|:.
  Fly   808 PSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEA 872

Human   522 THDHSLDIVFTWSFNGHLIDFDRDGD-----HFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTS 581
            ..|..|||.:.|..||.::..:.||.     .:.|         |.:.|..::.||.|.|:|:::
  Fly   873 AFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNR---------LTVHNTSMRDAGDYECVVKSA 928

Human   582 VDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVS 646
            |:.:|:...:.:.|.||.|..|.:.:|:.|.|.:.|..|..|...|..|.|..||.::..|..||
  Fly   929 VNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNRTWVNVS 993

Human   647 TVPELIDGKTFT----ATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVS 707
            |..:..:...:|    |.||.|.||..|||...|.|.:|||.||.||....|.|..|.:.|.||.
  Fly   994 THVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVG 1058

Human   708 GGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHP-FS 771
            ||||...:|.|||:.:..:.|:..|..|.|.::..|.:.|....:...|.......|..::. ::
  Fly  1059 GGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNNYYT 1123

Human   772 PFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPL----EKNRGR 832
            .:||||...|:.|:||.|...|::|||:.|...|....|.:.::|...|.| .|:    |..||:
  Fly  1124 EYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTW-QPIDMSRENIRGK 1187

Human   833 IQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTR 897
            :.|:.:|||:...:||::....:...:....|..|:....|.:.|.|||:||.||.|......|.
  Fly  1188 LIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTY 1252

Human   898 KPPPSQPPGNI-IWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELS 961
            :..|.:||.:: ::..:.|.:.:.|..|....:|..|:||||.. |  :|..::|..|.|.|.:.
  Fly  1253 RKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRI-W--ESDQNMITANNTIVPIG 1314

Human   962 LPFDEDYIIEIKP----------FSDGGDGSSSE---QIRIPKISNAYARGSGAST---SNACTL 1010
            ... |.||..:.|          :|:||||..|.   ..::.|.:.     :||:|   .|..|.
  Fly  1315 QKL-ESYINNLTPGKSYNMRVLAYSNGGDGRMSSPTLHFQMGKTTR-----NGANTRHGHNINTA 1373

Human  1011 SAISTIMISLT 1021
            ..:||:::..|
  Fly  1374 LILSTLLLIST 1384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNTN4	NP_001193884.1	Ig	25..118	CDD:325142	32/102 (31%)
		Ig	120..213	CDD:325142	30/95 (32%)
		Ig	225..313	CDD:325142	30/87 (34%)
		Ig	318..401	CDD:325142	28/87 (32%)
		Ig5_Contactin	422..494	CDD:319278	25/71 (35%)
		Ig6_Contactin-4	513..597	CDD:143261	23/88 (26%)
		FN3	597..690	CDD:238020	37/96 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..710		11/24 (46%)
		FN3	703..795	CDD:238020	29/92 (32%)
		FN3	804..896	CDD:238020	27/95 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..907		7/20 (35%)
		FN3	904..989	CDD:238020	27/98 (28%)
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	30/98 (31%)
		I-set	362..462	CDD:254352	30/99 (30%)
		Ig	466..559	CDD:299845	29/94 (31%)
		IG_like	584..657	CDD:214653	24/74 (32%)
		IGc2	586..645	CDD:197706	21/59 (36%)
		Ig	667..751	CDD:299845	28/83 (34%)
		IG_like	676..751	CDD:214653	27/74 (36%)
		IG_like	765..844	CDD:214653	25/78 (32%)
		Ig	773..844	CDD:299845	25/70 (36%)
		I-set	851..940	CDD:254352	24/97 (25%)
		Ig	866..944	CDD:299845	23/86 (27%)
		FN3	944..1043	CDD:238020	38/98 (39%)
		FN3	1053..1146	CDD:238020	28/92 (30%)
		fn3	1156..1244	CDD:278470	26/88 (30%)
		fn3	1259..1346	CDD:278470	26/90 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10321
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1415
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46028
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm41700
orthoMCL	1	0.900	-	-		OOG6_100978
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3370
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870