DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNTN4 and Cntn4

DIOPT Version :9

Sequence 1:	NP_001193884.1	Gene:	CNTN4 / 152330	HGNCID:	2174	Length:	1026	Species:	Homo sapiens
Sequence 2:	NP_446331.1	Gene:	Cntn4 / 116658	RGDID:	621361	Length:	1026	Species:	Rattus norvegicus

Alignment Length:	1026	Identity:	970/1026 - (94%)
Similarity:	1012/1026 - (98%)	Gaps:	0/1026 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLN 65
            |||||||||||||:||||||.|||||:|:||||.||||||||||||||:||||||||||||||||
  Rat     1 MRLPWELLVLQSFMLCLADDYTLHGPVFVQEPSHVMFPLDSEEKKVKLSCEVKGNPKPHIRWKLN 65

Human    66 GTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRS 130
            |||||.|||||||||||||||||||||||:|||||.||||||||||||||||||||:||||||||
  Rat    66 GTDVDIGMDFRYSVVEGSLLINNPNKTQDSGTYQCIATNSFGTIVSREAKLQFAYLENFKTRTRS 130

Human   131 TVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCV 195
            |||||||||||||||||||||||||||||||:||||||||||||||||||||||||:||||||||
  Rat   131 TVSVRRGQGMVLLCGPPPHSGELSYAWIFNEHPSYQDNRRFVSQETGNLYIAKVEKADVGNYTCV 195

Human   196 VTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWR 260
            ||||||:|:||||||||||||||||||||||||||||||||..||:||||||||||||||||:||
  Rat   196 VTNTVTSHQVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPAEKGSTVKLECFALGNPVPTILWR 260

Human   261 RADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDI 325
            ||||||||||||||||:||||||||||||||.||||||||||||:|:||:||||||||:|.||||
  Rat   261 RADGKPIARKARRHKSSGILEIPNFQQEDAGSYECVAENSRGKNIAKGQVTFYAQPNWVQIINDI 325

Human   326 HVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKH 390
            ||||||:|||||||||||||||:|||||:|||||:||||||||||||||||||||||||:|||||
  Rat   326 HVAMEESVFWECKANGRPKPTYRWLKNGDPLLTRERIQIEQGTLNITIVNLSDAGMYQCVAENKH 390

Human   391 GVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERIT 455
            |||:::|||||||..||||||||||||||||||||||||||||||:|||||:|||:||:||||||
  Rat   391 GVIYASAELSVIAESPDFSRTLLKRVTLVKVGGEVVIECKPKASPRPVYTWRKGREILRENERIT 455

Human   456 ISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQ 520
            ||||||||||||||||||||||||||||||||||||:||||||:|||||||||||||||||||||
  Rat   456 ISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNVVVKDPTKVMVPPSSMDVTVGESIVLPCQ 520

Human   521 VTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRL 585
            |||||||||||||:|||||||||:|||||||||||||||||||||||||||||||||||||||:|
  Rat   521 VTHDHSLDIVFTWTFNGHLIDFDKDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDKL 585

Human   586 SAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPE 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   586 SAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPE 650

Human   651 LIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSE 715
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   651 LVDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSE 715

Human   716 LVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVF 780
            ||||||||||||||||||||||||||:|||||||||||||||||||||||||.||||||||||||
  Rat   716 LVITWETVPEELQNGRGFGYVVAFRPHGKMIWMLTVLASADASRYVFRNESVRPFSPFEVKVGVF 780

Human   781 NNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHED 845
            ||||||||||||:||||||||||||||||||||||||||||||||:.||||||||||||||||:|
  Rat   781 NNKGEGPFSPTTLVYSAEEEPTKPPASIFARSLSATDIEVFWASPIGKNRGRIQGYEVKYWRHDD 845

Human   846 KEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIW 910
            ||||||||||||||||||||||||:.||||:||||||||||||||.|||||||||||||||||||
  Rat   846 KEENARKIRTVGNQTSTKITNLKGNALYHLSVKAYNSAGTGPSSAAVNVTTRKPPPSQPPGNIIW 910

Human   911 NSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPF 975
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   911 NSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPF 975

Human   976 SDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL 1026
            |||||||||||||||||||:|||||||||||||||||||||||||||||||
  Rat   976 SDGGDGSSSEQIRIPKISNSYARGSGASTSNACTLSAISTIMISLTARSSL 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNTN4	NP_001193884.1	Ig	25..118	CDD:325142	85/92 (92%)
		Ig	120..213	CDD:325142	87/92 (95%)
		Ig	225..313	CDD:325142	78/87 (90%)
		Ig	318..401	CDD:325142	72/82 (88%)
		Ig5_Contactin	422..494	CDD:319278	66/71 (93%)
		Ig6_Contactin-4	513..597	CDD:143261	80/83 (96%)
		FN3	597..690	CDD:238020	91/92 (99%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..710		24/24 (100%)
		FN3	703..795	CDD:238020	88/91 (97%)
		FN3	804..896	CDD:238020	84/91 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..907		19/20 (95%)
		FN3	904..989	CDD:238020	84/84 (100%)
Cntn4	NP_446331.1	Ig	25..114	CDD:299845	81/88 (92%)
		I-set	26..117	CDD:254352	83/90 (92%)
		Ig	120..213	CDD:299845	87/92 (95%)
		IG_like	130..204	CDD:214653	70/73 (96%)
		Ig	225..313	CDD:299845	78/87 (90%)
		IG_like	232..311	CDD:214653	70/78 (90%)
		I-set	316..401	CDD:254352	74/84 (88%)
		Ig	318..401	CDD:299845	72/82 (88%)
		IG_like	415..494	CDD:214653	73/78 (94%)
		Ig5_Contactin_like	422..494	CDD:143170	66/71 (93%)
		IG_like	504..593	CDD:214653	85/88 (97%)
		Ig6_Contactin-4	513..597	CDD:143261	80/83 (96%)
		FN3	597..690	CDD:238020	91/92 (99%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..710		24/24 (100%)
		FN3	703..792	CDD:238020	86/88 (98%)
		FN3	804..896	CDD:238020	84/91 (92%)
		FN3	904..989	CDD:238020	84/84 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83696378
Domainoid	1	1.000	270	1.000	Domainoid score	I17495
eggNOG	1	0.900	-	-		E1_KOG3513
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14257
Inparanoid	1	1.050	1997	1.000	Inparanoid score	I1448
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46028
OrthoDB	1	1.010	-	-		D24313at9347
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		oto135721
orthoMCL	1	0.900	-	-		OOG6_100978
Panther	1	1.100	-	-	LDO	PTHR10075
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270