Protein Alignment CUX1 and cone-1

DIOPT Version :10

• Sequence 1: NP_001189472.1
• Gene: CUX1 / 1523
• HGNCID: 2557
• Length: 1516
• Species: Homo sapiens
• Sequence 2: NP_497577.2
• Gene: cone-1 / 175372
• WormBaseID: WBGene00306126
• Length: 621
• Species: Caenorhabditis elegans
• Alignment Length: 641
• Identity: 164/641 - (25%)
• Similarity: 281/641 - (43%)
• Gaps: 125/641 - (19%)

Human    12 WKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEID 76
            |:..|..::|..::|..|.|..|||:||..:.||:|:|..::..|.:|.||...||:|:||.|.|
 Worm     8 WESVDWDRIQTRVEAEVTALGQRQDDSEIRKTRLVEESNAYRGRTNKDSRKVAIPLIKAFQSEFD 72

Human    77 ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFA 141
            .|..||..||.|.:::.|.::.:|||...|...:..:...::......|.::|:..|.:.|.|..
 Worm    73 GLLARSTAAENALIDICKSIVSLPDPKSLLKGAEAWKNDAEKTQKAVEEREELKRQLIKVNNELE 137

Human   142 EVKNQEVTIKALKEKIREYEQT----LKNQAETIALEKEQKLQND-----FAEKERKLQETQMST 197
            :::.::|.::.||:|:.:.|..    ::|....:..:.||:| ||     .|||| |::|.....
 Worm   138 DLRGKDVKVRKLKDKLAKLESEQDIFIENAVNEVEKKAEQEL-NDRLTELIAEKE-KMKEQNEIL 200

Human   198 TSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAE 262
            ...::..|.|.:.:|..||..:            :|..:.|.:|         |::..:|.::
 Worm   201 EKNMDSLESKNKDIQRKLEIAK------------QTVEQKDGLE---------NEQLSIAMKD-- 242

Human   263 TLREQLSSANHSL--------QLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQR 319
                 |:.|.|.:        ||.::.:|..:.::|..:...::|...|..|:..|.||..|::|
 Worm   243 -----LADAKHKIVFLEERVSQLENEAEKVNESKKAGNIEDIAALGSVLVQKDDVIQQLTNDIKR 302

Human   320 LQASLTKLRENSASQISQLEQQLSAKNST----LKQLEEKLKGQADYEEVKKELNILKSMEFAPS 380
            .:||..:........:|.:|:    ||.|    |.:|:.:|:.:.|||.:|.||.:|:.:||..|
 Worm   303 HEASHVEELAKWKLAVSAVEK----KNKTLIGELNELKNQLESRNDYEAIKNELRLLREIEFGDS 363

Human   381 EGAGTQ------DAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR--------KGKDQPES 431
            ..|..:      :..:.|:.||.||||.||:|||:||::|....|....        |.|.:...
 Worm   364 AEANAESIERLGETVETLDRLLAEKNRRLQNENASLRVANDGFKGRNEEQEAELTVLKEKSERND 428

Human   432 RRPGSLPAPPPSQ-----LPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFAL 491
            |....|.|...|.     :|...|     ||...:.:||....|   :||    :|:.::.:
 Worm   429 RLIAQLEADLASAVQDIGIPERMG-----TNEMLKDAPAPTISD---ASL----VPILTSQR--- 478

Human   492 NSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVN-------GMAPSPSQ 549
            |.|.:|       ..:::||.|..        .|..:|.|:.:::..:.|       ....||..
 Worm   479 NRLHER-------VTSLEEAISLE--------KTKQLSVQNEIERVREENIRLCERIRFLQSPGG 528

Human   550 SESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPK 605
            .:.| :|..|...|.....|..|..|           |....|:.|..  |||.||
 Worm   529 QQQA-NVEAGLGNDFRNGNRNKKVSL-----------HDKTTLNMGRA--ILATPK 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CUX1	NP_001189472.1	SMC_prok_B	<107..411	CDD:274008	80/330 (24%)
		CUT	558..634	CDD:460543	13/48 (27%)
		PHA03247	758..>944	CDD:223021
		CUT	950..1018	CDD:460543
		CUT	1133..1210	CDD:460543
		Homeodomain	1256..1312	CDD:459649
		PHA03307	<1325..>1398	CDD:223039
cone-1	NP_497577.2	SMC_prok_B	<111..445	CDD:274008	90/367 (25%)
		CASP_C	414..594	CDD:462392	43/201 (21%)