DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Foxg1 and FoxK

DIOPT Version :9

Sequence 1:	NP_001153584.1	Gene:	Foxg1 / 15228	MGIID:	1347464	Length:	481	Species:	Mus musculus
Sequence 2:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	387	Identity:	117/387 - (30%)
Similarity:	167/387 - (43%)	Gaps:	59/387 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    31 DNHHASHGHHNSHHPQHHHHHHHHHHPPP---PAPQPPPPPPQQQQQQP-----PPAPQPPQARG 87
            |..|....||:...| |.....|.||||.   |..|      |||||||     |..|..|....
  Fly   293 DELHQQQLHHHQQQP-HLQQQQHPHHPPAHHLPLQQ------QQQQQQPAHHPLPHTPHHPLHHT 350

Mouse    88 APAADDDKGPQPLLLPPSTALDGAKADALGAKGEPGGGPAELAPVG---PDEKEKG--------A 141
            |......:....::.||:    ||.|..:.     |.||...:|:.   |.:::|.        .
  Fly   351 ALHQQQQRSGSIVVAPPA----GAAAHLIA-----GDGPGIYSPLKISIPKKEQKSPYLSPTGTI 406

Mouse   142 GAGGEEKKGAGEGGKDGEGGKEGDKKNGK---------------YEKPPFSYNALIMMAIRQSPE 191
            .|.........:|....:.....:..|..               .||||:||..||:.||..:|:
  Fly   407 SAANSCPASPRQGFIQNQPNNYNNYGNNNTQDLFQTPSTASYNHNEKPPYSYAQLIVQAISAAPD 471

Mouse   192 KRLTLNGIYEFIMKNFPYYR-ENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDD 255
            |:|||:|||.||:|::|||| |..:|||||||||||||:.|:||.|..|:||||::|.:||.|..
  Fly   472 KQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGA 536

Mouse   256 VFIGGTTGKLRRRSTTS-RAKLAFKRGARLTSTGLTFMDRAGSLY------WPMSPFLSLHHPRA 313
            ..|..:..|.|:||:.. |......|.|.::.:.:.....:..|.      .|.||.:||....|
  Fly   537 KLIDHSYKKRRQRSSQGFRPPYGMPRSAPVSPSHMDNSRESSPLQDIVLQSAPGSPGMSLEQRAA 601

Mouse   314 SSTLSYNGTTSAYPSHPMPYSSVLTQNSLGNNHSFSTANGLSVDRLVNGEIPYATHHLTAAA 375
            ...:.|| :.:|:............|....|::.:|:.:...|....:|.....||...:||
  Fly   602 DPEIIYN-SQNAHQQQQQQQQQQQQQTLSNNSNQYSSGSPYYVTNQSSGVATPQTHVEGSAA 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Foxg1	NP_001153584.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..173		38/175 (22%)
		FH	173..261	CDD:214627	52/88 (59%)
		Required for interaction with TLE6. /evidence=ECO:0000269\|PubMed:16314515	241..336		26/101 (26%)
		Interaction with KDM5B. /evidence=ECO:0000250	375..398		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..447
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	51/86 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850