DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hey2 and E(spl)m8-HLH

DIOPT Version :9

Sequence 1:	NP_038932.1	Gene:	Hey2 / 15214	MGIID:	1341884	Length:	339	Species:	Mus musculus
Sequence 2:	NP_524513.1	Gene:	E(spl)m8-HLH / 43161	FlyBaseID:	FBgn0000591	Length:	179	Species:	Drosophila melanogaster

Alignment Length:	159	Identity:	40/159 - (25%)
Similarity:	73/159 - (45%)	Gaps:	27/159 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse    41 TTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQA 105
            ||.:||. :|.::.::|::||.|:|..|..|:.||.......|..:::|||:|:..|..::. |.
  Fly     4 TTKTQIY-QKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLESAVIFMRQ-QK 66

Mouse   106 TGGKGYFDAHALATDFMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLS------------ 158
            |..|...:..:|..|....|:...:.||:|.::|..|:  |..|...:::||.
  Fly    67 TPKKVAQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGM--SVDLGKSVMTHLGRVYKNLQQFHEA 129

Mouse   159 -----------TCASQREAAVMTSSMAHH 176
                       .|:|..:|.:..:|..:|
  Fly   130 QSAADFIQNSMDCSSMDKAPLSPASSGYH 158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hey2	NP_038932.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		5/10 (50%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000269\|PubMed:11486045	47..116		19/68 (28%)
		HLH	49..105	CDD:238036	16/55 (29%)
		ORANGE	120..165	CDD:128787	13/67 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..339
		YQPW motif	329..332
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	17/58 (29%)
E(spl)m8-HLH	NP_524513.1	ORANGE	81..125	CDD:128787	11/45 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830867
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740