Protein Alignment Hey2 and E(spl)m3-HLH

DIOPT Version :9

• Sequence 1: NP_038932.1
• Gene: Hey2 / 15214
• MGIID: 1341884
• Length: 339
• Species: Mus musculus
• Sequence 2: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Alignment Length: 300
• Identity: 59/300 - (19%)
• Similarity: 103/300 - (34%)
• Gaps: 103/300 - (34%)

Mouse    49 RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS--AKLEKAEILQMTVDHLKMLQATGG--- 108
            ||..:.::|::||.|||..|.:|:.|:....:::|.  .:||||:||::||||::.|:..||
  Fly    12 RKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGLSL 76

Mouse   109 KGYF-----------DAHALATDFMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLSTCAS 162
            :|..           .||  ...|.| |:.....::.:.|...:   .:|.:..:::..|||...
  Fly    77 QGVVAGVGSPPTSTSTAH--VESFRS-GYVHAADQITQVLLQTQ---QTDEIGRKIMKFLSTRLI 135

Mouse   163 QREAAVMTSSMAHHHHPLHPHHWAAAFHHLPTALLQPNGLHTSESTPCRLSTSSEVPSAHGSALL 227
            :.:..::........|                                   ...::|.:.|
  Fly   136 ELQTQLLQQQQQQQQH-----------------------------------QQQQIPQSSG---- 161

Mouse   228 TATFAHADSALRMPSGGTVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPSN 292
                     .|..|..|...|                  |||||..:..||         :...:
  Fly   162 ---------RLAFPLLGGYGP------------------AAAAAAISYSSF---------LTSKD 190

Mouse   293 AAAAAAVAAATAISPPLSVSAASSPQQTSTGTNNKPYQPW 332
            ...........|:|...|||:..|      |.:...::||
  Fly   191 ELIDVTSVDGNALSETASVSSQES------GASEPVWRPW 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hey2	NP_038932.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		2/2 (100%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000269|PubMed:11486045	47..116		27/82 (33%)
		HLH	49..105	CDD:238036	23/57 (40%)
		ORANGE	120..165	CDD:128787	8/44 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..339		6/22 (27%)
		YQPW motif	329..332		0/2 (0%)
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	23/57 (40%)
		ORANGE	96..136	CDD:128787	8/43 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830864
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740