DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hey2 and dpn

DIOPT Version :9

Sequence 1:	NP_038932.1	Gene:	Hey2 / 15214	MGIID:	1341884	Length:	339	Species:	Mus musculus
Sequence 2:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster

Alignment Length:	335	Identity:	102/335 - (30%)
Similarity:	152/335 - (45%)	Gaps:	43/335 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 ESDLDETIDVGSENNYPGHATSSVMRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLV 75
            ::|::...|....|.|.....|:...|| |...|:...||..:.|:|||||.|||:.|:||:.|:
  Fly     4 KNDINSDDDFDCSNGYSDSYGSNGRMSN-PNGLSKAELRKTNKPIMEKRRRARINHCLNELKSLI 67

Mouse    76 PTAFEKQGS--AKLEKAEILQMTVDHLKMLQATGGKGYFDAHALATDFMSIGFRECLTEVARYLS 138
            ..|.:|..:  .|||||:||:|||.||:.:|.........:..........||.||..||.||:|
  Fly    68 LEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMAIQSDPSVVQKFKTGFVECAEEVNRYVS 132

Mouse   139 SVEGLDPSDPLRVRLVSHLSTCASQREAAVMTSSMAH-HHHPLHPHHWAAAFHHLPTALLQ--PN 200
            .::|:|..  :|.||.:||:.||:..|.....|:.:: :...|.|   |.|....||.|..  |.
  Fly   133 QMDGIDTG--VRQRLSAHLNQCANSLEQIGSMSNFSNGYRGGLFP---ATAVTAAPTPLFPSLPQ 192

Mouse   201 GLHTSESTPCRLSTSSEVPSAH--GSALLTATFAHADSALRMPSGGTVAPCVPPLSTSLLSLSAT 263
            .|:.:.      .|.|..|:..  |..|:.:.....:.||.||:.|:.||  ||...:....:|.
  Fly   193 DLNNNS------RTESSAPAIQMGGLQLIPSRLPSGEFALIMPNTGSAAP--PPGPFAWPGSAAG 249

Mouse   264 VHAAAAAATAAAHSFPL---SFAGAFPM--------------LPSN----AAAAAAVAAATAISP 307
            |.|..|:|..|:.:.|.   .:..:|.|              ||.|    ......:....:.||
  Fly   250 VAAGTASAALASIANPTHLNDYTQSFRMSAFSKPVNTSVPANLPENLIHTLPGQTQLPVKNSTSP 314

Mouse   308 PLS-VSAASS 316
            ||| :|:.||
  Fly   315 PLSPISSISS 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hey2	NP_038932.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		11/40 (28%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000269\|PubMed:11486045	47..116		30/70 (43%)
		HLH	49..105	CDD:238036	29/57 (51%)
		ORANGE	120..165	CDD:128787	18/44 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..339		4/8 (50%)
		YQPW motif	329..332
dpn	NP_476923.1	HLH	39..101	CDD:238036	30/61 (49%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	18/45 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810