Protein Alignment Hey1 and E(spl)m8-HLH

DIOPT Version :10

• Sequence 1: NP_034553.2
• Gene: Hey1 / 15213
• MGIID: 1341800
• Length: 299
• Species: Mus musculus
• Sequence 2: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Alignment Length: 173
• Identity: 45/173 - (26%)
• Similarity: 77/173 - (44%)
• Gaps: 17/173 - (9%)

Mouse    39 MSPTTSSQVLARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKM 103
            |..||.:|:. :|.::.::|::||.|:|..|..|:.||.......|..:::|||:|:..|..::.
  Fly     1 MEYTTKTQIY-QKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLESAVIFMRQ 64

Mouse   104 LHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHL----NNYASQ 164
            ..|. .|...:..:|.:|....|:...:.||:|.::...|:  |..|...:::||    .|....
  Fly    65 QKTP-KKVAQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGM--SVDLGKSVMTHLGRVYKNLQQF 126

Mouse   165 REAASGAH--------GGLGHIPWGSA-FGHHPHIAHPLLLPQ 198
            .||.|.|.        ..:...|...| .|:|.....|...||
  Fly   127 HEAQSAADFIQNSMDCSSMDKAPLSPASSGYHSDCDSPAPSPQ 169

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hey1	NP_034553.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		5/13 (38%)
		bHLH_SF	41..122	CDD:469605	22/80 (28%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	48..117		18/68 (26%)
		ORANGE	120..166	CDD:128787	11/49 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..234		2/5 (40%)
		YRPW motif	289..292
E(spl)m8-HLH	NP_524513.1	bHLH-O_ESM5_like	12..70	CDD:381486	17/58 (29%)
		ORANGE	81..125	CDD:128787	11/45 (24%)