DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hey1 and E(spl)m8-HLH

DIOPT Version :9

Sequence 1:	NP_034553.2	Gene:	Hey1 / 15213	MGIID:	1341800	Length:	299	Species:	Mus musculus
Sequence 2:	NP_524513.1	Gene:	E(spl)m8-HLH / 43161	FlyBaseID:	FBgn0000591	Length:	179	Species:	Drosophila melanogaster

Alignment Length:	173	Identity:	45/173 - (26%)
Similarity:	77/173 - (44%)	Gaps:	17/173 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse    39 MSPTTSSQVLARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKM 103
            |..||.:|:. :|.::.::|::||.|:|..|..|:.||.......|..:::|||:|:..|..::.
  Fly     1 MEYTTKTQIY-QKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLESAVIFMRQ 64

Mouse   104 LHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHL----NNYASQ 164
            ..|. .|...:..:|.:|....|:...:.||:|.::...|:  |..|...:::||    .|....
  Fly    65 QKTP-KKVAQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGM--SVDLGKSVMTHLGRVYKNLQQF 126

Mouse   165 REAASGAH--------GGLGHIPWGSA-FGHHPHIAHPLLLPQ 198
            .||.|.|.        ..:...|...| .|:|.....|...||
  Fly   127 HEAQSAADFIQNSMDCSSMDKAPLSPASSGYHSDCDSPAPSPQ 169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hey1	NP_034553.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		5/13 (38%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	48..117		18/68 (26%)
		HLH	50..107	CDD:238036	16/56 (29%)
		ORANGE	120..166	CDD:128787	11/49 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..234		2/5 (40%)
		YRPW motif	289..292
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	16/57 (28%)
E(spl)m8-HLH	NP_524513.1	ORANGE	81..125	CDD:128787	11/45 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830843
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740