DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NEK10 and nekl-4

DIOPT Version :9

Sequence 1:	NP_001381899.1	Gene:	NEK10 / 152110	HGNCID:	18592	Length:	1172	Species:	Homo sapiens
Sequence 2:	NP_498178.3	Gene:	nekl-4 / 175760	WormBaseID:	WBGene00017033	Length:	981	Species:	Caenorhabditis elegans

Alignment Length:	1124	Identity:	349/1124 - (31%)
Similarity:	557/1124 - (49%)	Gaps:	242/1124 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    83 ELENFSINYKNERNFSKHPQRKLFQEIFTALVKNRLISREWVNRAPSIHFLRVLICL-RLLMRDP 146
            :|||      |..:.|.|       |:.|.|::||:..||::...|:..::.::..| |.|.||.
Worm    38 QLEN------NLDSLSIH-------ELSTNLIRNRICCREFIESRPAKKWVFLIFRLARTLFRDK 89

Human   147 CYQEILHSLGGIENL-----------------------AQYMEIVANEYLGYGEEQH----TVDK 184
            ......||:    ||                       .|..:.:|:.:|   ..:|    ||..
Worm    90 TRIATFHSV----NLHSEFVQVFWRNLTYQTKSYRNCKFQTFQFIASRFL---RSEHDWNVTVVN 147

Human   185 LVNMTYIFQKLA-AVKDQREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLAE-SQECREKIS 247
            .:|:|   |||. ..::.|::|..:.....|| ||..|...||..||..|..|:: |..|||.:.
Worm   148 CLNVT---QKLIDNGENARKFVDCNLEDAVLV-LLATRQMTVLQHSLEILGRLSDWSTTCRENLC 208

Human   248 ELNIVENLLMILHEYDLLSKRLTAELLRLLCAEPQVKEQVKLYEGIPVLLSLLHSDHLKLLWSIV 312
            |.|.::..|.::.:.|:|:::|...|||:|..|.|.:||:::|:|:|.||.||...:.:|.|.:.
Worm   209 ESNTIDVCLQLIPDGDILTQKLCISLLRILSCEEQAREQIRIYDGVPTLLGLLSIKNSRLQWHVA 273

Human   313 WILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDHSSIGSLSSANAAGRIQQLHLSEDLSP 377
            |.|.|:.|..|||:||...|||..:.                       ||       :|....|
Worm   274 WTLAQLAEQHETSLEIAQLGGISLIF-----------------------AA-------ISNPKPP 308

Human   378 REIQENTFSLQAACCAALTELVLNDTNAHQVVQENGVYTIAKLILPNKQKNAAKS----NLLQCY 438
            .:...:..::.....|.|.:|....:|...:...||||.:.||:...|.....::    :||||.
Worm   309 GKAVGDWVAMLTGLTALLAQLAQASSNQQLMSNANGVYILGKLLAIKKNVTTDETIDSWDLLQCS 373

Human   439 AFRALRFLFSMERNRPLFKRLFPTDLFEIFIDIGHYVRDISAYEELVSKLNLLVEDELKQIAENI 503
            .||.||.:::.||:|.|.|::.||::||.|:|:|:|...::.|:::....:.|:|:.: :|.::.
Worm   374 IFRVLRLMYTFERSRQLLKKVLPTEIFEKFVDVGNYNSVLTDYDQIAKMYDNLIEENI-EIMKDW 437

Human   504 ESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRK----HSGQ--NLLAMKEVNLHNPAFGKDKK 562
            |::|:.:..:..:|.|.:||.||:|||||||.|||    ||..  .|||:||:.:.|    .:.:
Worm   438 ETVNERRQAVGEVGEYELLDQLGAGAFGCVYTVRKKAQSHSENPAKLLALKEIFMTN----LNDR 498

Human   563 DRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFT 627
            :.|.|..:::||:.|||:||.|||||||.:.|:||.||||||:||:|..|.:...::|||..:|.
Worm   499 ESDKSFGDMISEVKIIKQQLRHPNIVRYRRIFVENHRLYIVMDLIQGCSLRDLIITMKEKKGNFE 563

Human   628 EERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKLTSVVGT 692
            |:::|.:.:|:.||||||||||:||||||.|||||:...::|.:|||||||||.. ..|.|..||
Worm   564 EKKIWAMVVQMMLALRYLHKEKQIVHRDLKPNNIMMTTDERVVITDFGLAKQKGP-EYLKSAAGT 627

Human   693 ILYSCPEVLKSEPYGEKADVWAVGCILYQMATLSPPFYSTNMLSLATKIVEAVYEPVPEGIYSEK 757
            |:|||||::::.|||||||:|:.||.:|:|..|.|.|:|||||:||.:||||.|:|:.| ::|:.
Worm   628 IIYSCPEIVQNLPYGEKADIWSFGCCIYEMCQLQPVFHSTNMLTLAMQIVEAKYDPLNE-MWSDD 691

Human   758 VTDTISRCLTPDAEARPDIVEVSSMISDVMMKYLDNLSTSQLSLEKKLERERRRTQRYFMEANRN 822
            :...|:.||.||..|||||::||.|....:::|||:::..|
Worm   692 LRFLITSCLAPDPSARPDILKVSGMCGVRLLEYLDDVARQQ------------------------ 732

Human   823 TVTCHHELAVLSHETFEKASLSSSSSGAASLKSELSESADLPPEGFQASYGKDEDRACDEILSDD 887
                                 :|:|...||                |:||
Worm   733 ---------------------ASTSDMTAS----------------QSSY--------------- 745

Human   888 NFNLENAEKDTYSEVDDELDISDNSSSSSSSPLKESTFNILKRSFSASGGER-----QSQTRDFT 947
              |:             ::|.|.:|.:||:|..|..     .||...||..:     .:..|:.:
Worm   746 --NI-------------KIDESPSSLNSSTSSYKRP-----GRSSKTSGSGKLPPINPAPRRNHS 790

Human   948 GGTGSRPRPA---LLP-----LDLLLKVPPHML--RAHIKEIEAELVTGWQSHSLPAVILRNLKD 1002
            ...|..|||:   .||     ..::....|..:  |..::....|       |...:.....||
Worm   791 MSAGETPRPSSIVCLPRITDKYSVMFPSAPSAIPSRRRVQTCSTE-------HPARSSSSTELK- 847

Human  1003 HGPQMGTFLWQASAGIAVSQRKVRQISDPIQQILIQLHKIIYITQ---LPPALHHNLKRRVIERF 1064
                    :.:.|.|:.||...:|||.||:..||.|:|:|:.:|.   :..:::|  :||::|.|
Worm   848 --------VSKQSDGLTVSSNVLRQIQDPVLTILNQIHRILVVTDKETISTSMNH--QRRLVEMF 902

Human  1065 KKSLFSQQSNPCNLKSEIKKLSQGSPEPIEPNFFTADYHLLHRSSGGNSLSPNDPTGLPTSIELE 1129
            :|:|..::::...:|:.::||:..|||.|:.|...:|:..:...|..|....:...
Worm   903 RKNLLGRENDAVQMKTHLRKLAAESPEEIQMNLGFSDFRPVLVQSHINGYQKDQKV--------- 958

Human  1130 EGITYEQMQTVIEEVLEES 1148
            ..|||||:...||.::.|:
Worm   959 TKITYEQLSACIECLIAEN 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEK10	NP_001381899.1	ARM	209..251		16/42 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..875		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	898..954		13/60 (22%)
nekl-4	NP_498178.3	PKc_like	452..719	CDD:304357	143/272 (53%)
nekl-4	NP_498178.3	S_TKc	453..710	CDD:214567	138/262 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	274	1.000	Domainoid score	I1049
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	514	1.000	Inparanoid score	I768
Isobase	1	0.950	-	0	Normalized mean entropy	S12200
OMA	1	1.010	-	-		QHG59808
OrthoDB	1	1.010	-	-		D1290401at2759
OrthoFinder	1	1.000	-	-		FOG0008869
OrthoInspector	1	1.000	-	-		oto23263
orthoMCL	1	0.900	-	-		OOG6_109789
Panther	1	1.100	-	-	LDO	PTHR43671
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2674
SonicParanoid	1	1.000	-	-		X6620
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.820