DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hes3 and h

DIOPT Version :9

Sequence 1:	XP_011248491.1	Gene:	Hes3 / 15207	MGIID:	104877	Length:	291	Species:	Mus musculus
Sequence 2:	NP_001014577.1	Gene:	h / 38995	FlyBaseID:	FBgn0001168	Length:	337	Species:	Drosophila melanogaster

Alignment Length:	205	Identity:	57/205 - (27%)
Similarity:	93/205 - (45%)	Gaps:	27/205 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    91 GTASVAQPAASERSGVLKGMGISKPLMEKKRRARINVSLEQLRSL-LERHYSHQIRKRKLEKADI 154
            |||.|  ||..:.:.:......:||:|||:||||||..|.:|::| |:.......|..|||||||
  Fly    15 GTAVV--PAQLKETPLKSDRRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARHSKLEKADI 77

Mouse   155 LELSVKYMRSLQNSLQGLWPV--PSGVD-YPSGFQGGLRGVSQ--RLRPGEGD----------SG 204
            ||.:||:::.||.....:...  |..|: :.:||...:..||:  .:.|.:..          :|
  Fly    78 LEKTVKHLQELQRQQAAMQQAADPKIVNKFKAGFADCVNEVSRFPGIEPAQRRRLLQHLSNCING 142

Mouse   205 LRCPLLLQRREGS---------TTDSANPQATSVLNPCLPAIWAPSRAAGGSHSPQSPLPLPGGL 260
            ::..|..|:|:..         .:..::|:..|......|.::...:.|.|...|.....:|..|
  Fly   143 VKTELHQQQRQQQQQSIHAQMLPSPPSSPEQDSQQGAAAPYLFGIQQTASGYFLPNGMQVIPTKL 207

Mouse   261 LESSTDVVAP 270
            ...|..:|.|
  Fly   208 PNGSIALVLP 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hes3	XP_011248491.1	bHLH-O_HES3	117..171	CDD:381503	27/54 (50%)
h	NP_001014577.1	HLH	29..88	CDD:238036	27/58 (47%)
h	NP_001014577.1	ORANGE	106..141	CDD:128787	5/34 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910