DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hes2 and cwo

DIOPT Version :9

Sequence 1:	NP_001288734.1	Gene:	Hes2 / 15206	MGIID:	1098624	Length:	157	Species:	Mus musculus
Sequence 2:	NP_524775.1	Gene:	cwo / 44669	FlyBaseID:	FBgn0259938	Length:	698	Species:	Drosophila melanogaster

Alignment Length:	164	Identity:	46/164 - (28%)
Similarity:	68/164 - (41%)	Gaps:	34/164 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 EDAAEL---RKN----LKPL----LEKRRRARINESLSQLKGLVLPLLGAETSRSSKLEKADILE 61
            ||.||.   |:|    ..||    :|||||.|:|..|:.|..|:.|..  :.....::||.:|:|
  Fly    46 EDDAEYATGRRNKTSRQDPLSHRIIEKRRRDRMNSCLADLSRLIPPQY--QRKGRGRIEKTEIIE 108

Mouse    62 MTVRFLQEQPATLYSSAAPGPLNSYLEGYRACLARLARVL------PACSVLEPAVSARLLEHLR 120
            |.:|.|:.     ..|......:.|..||..|:...|:.|      ..|..|    ..||.||:.
  Fly   109 MAIRHLKH-----LQSECQQKESDYRSGYMDCMKEAAKFLYDVHMQDFCHRL----LGRLQEHID 164

Mouse   121 QRTVSD---DSPSLTLP---PAPAPAPSPPVPPP 148
            :...:|   .:.|..:|   .|.:.:|.....||
  Fly   165 EMFKTDCYKSTRSCHMPDNVSASSGSPHQAYHPP 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hes2	NP_001288734.1	bHLH_SF	10..73	CDD:381792	24/73 (33%)
		ORANGE	85..123	CDD:128787	12/43 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..157		7/31 (23%)
		WRPW motif	154..157
cwo	NP_524775.1	HLH	66..118	CDD:306515	18/58 (31%)
cwo	NP_524775.1	ORANGE	126..168	CDD:128787	12/45 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830932
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740