DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hes2 and dpn

DIOPT Version :9

Sequence 1:	NP_001288734.1	Gene:	Hes2 / 15206	MGIID:	1098624	Length:	157	Species:	Mus musculus
Sequence 2:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster

Alignment Length:	154	Identity:	56/154 - (36%)
Similarity:	80/154 - (51%)	Gaps:	20/154 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 AELRKNLKPLLEKRRRARINESLSQLKGLVLPLLGAETSRSSKLEKADILEMTVRFL---QEQPA 72
            |||||..||::|||||||||..|::||.|:|..:..:.:|.:||||||||||||:.|   |.|..
  Fly    38 AELRKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQL 102

Mouse    73 TLYSSAAPGPLNSYLEGYRACLARLARVLPACSVLEPAVSARLLEHLRQ--------RTVSDDS- 128
            .:...:.|..:..:..|:..|...:.|.:.....::..|..||..||.|        .::|:.|
  Fly   103 NMAIQSDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLNQCANSLEQIGSMSNFSN 167

Mouse   129 -------PSLTLPPAPAPA-PSPP 144
                   |:..:..||.|. ||.|
  Fly   168 GYRGGLFPATAVTAAPTPLFPSLP 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hes2	NP_001288734.1	bHLH_SF	10..73	CDD:381792	37/64 (58%)
		ORANGE	85..123	CDD:128787	9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..157		9/30 (30%)
		WRPW motif	154..157
dpn	NP_476923.1	HLH	39..101	CDD:238036	35/61 (57%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	9/43 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.870