DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hes1 and cwo

DIOPT Version :9

Sequence 1:	NP_032261.1	Gene:	Hes1 / 15205	MGIID:	104853	Length:	282	Species:	Mus musculus
Sequence 2:	NP_524775.1	Gene:	cwo / 44669	FlyBaseID:	FBgn0259938	Length:	698	Species:	Drosophila melanogaster

Alignment Length:	311	Identity:	72/311 - (23%)
Similarity:	111/311 - (35%)	Gaps:	81/311 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 ATPASVNTTPDKPKTASEHRKSSKP------IMEKRRRARINESLSQLKTLILDALKKDSSRHSK 74
            :|.|:..:..|.........|:|:.      |:|||||.|:|..|:.|..||....::..  ..:
  Fly    38 STSATAYSEDDAEYATGRRNKTSRQDPLSHRIIEKRRRDRMNSCLADLSRLIPPQYQRKG--RGR 100

Mouse    75 LEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFL------STCEGVNT 133
            :||.:|:||.::||::||        |........||:|:.:||.|..:||      ..|.
  Fly   101 IEKTEIIEMAIRHLKHLQ--------SECQQKESDYRSGYMDCMKEAAKFLYDVHMQDFCH---- 153

Mouse   134 EVRTRLLGHL---------ANCMTQINAMTYPGQAHPALQAPPPPPPSGPAGPQHAPFAPPPPPL 189
                ||||.|         .:|.....:...|...            |..:|..|..:.||...|
  Fly   154 ----RLLGRLQEHIDEMFKTDCYKSTRSCHMPDNV------------SASSGSPHQAYHPPLCHL 202

Mouse   190 VPIPGGAAPPPGSA----------------PCKLGSQAGEAAKVFGGFQVV-----PAPDGQFAF 233
            ..:...:|.....:                ..:...||..||.|......|     ||.:.....
  Fly   203 RDMLATSASDVEHSQDHNDVKDLSFRNHLNQLQRSQQAAAAAAVAAAAVAVANGSSPASNAGVDS 267

Mouse   234 LIP--NGAFAHSGPV----IPVYTSNSGTS---VGPNAVSPSSGSSLTSDS 275
            .:|  ||......|.    :|..::.||::   .|.|:.|..|.||..:.|
  Fly   268 KVPLTNGGGTGGAPPAADNVPSNSTGSGSAAACAGGNSNSSGSNSSNAASS 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hes1	NP_032261.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		6/33 (18%)
		HLH	32..95	CDD:238036	23/68 (34%)
		Hairy_orange	110..148	CDD:284859	15/52 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..204		7/61 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..282		7/23 (30%)
		WRPW motif	277..280
cwo	NP_524775.1	HLH	66..118	CDD:306515	19/53 (36%)
cwo	NP_524775.1	ORANGE	126..168	CDD:128787	14/49 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830930
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740