Protein Alignment Hes1 and E(spl)m5-HLH

DIOPT Version :9

• Sequence 1: NP_032261.1
• Gene: Hes1 / 15205
• MGIID: 104853
• Length: 282
• Species: Mus musculus
• Sequence 2: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Alignment Length: 263
• Identity: 55/263 - (20%)
• Similarity: 98/263 - (37%)
• Gaps: 87/263 - (33%)

Mouse    18 PASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILE 82
            |.|.|:|....|| ..:.|..||::|::||||:|:.|..||||:.:....|:.  .:::||::||
  Fly     3 PQSNNSTTFVSKT-QHYLKVKKPLLERQRRARMNKCLDTLKTLVAEFQGDDAI--LRMDKAEMLE 64

Mouse    83 MTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCM 147
            ..:..:|. |..:..|.:|  |..:..::.|:...::|::|.::....::.:|...::.||.
  Fly    65 AALVFMRK-QVVKQQAPVS--PLPMDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLG--- 123

Mouse   148 TQINAMTYPGQAHPALQAPPPPPPSGPAGPQHAPFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAG 212
            .:...|....|...::....|.|.|
  Fly   124 VEFQRMLQADQVQTSVTTSTPRPLS---------------------------------------- 148

Mouse   213 EAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTSDSMW 277
                        ||..|                    |.|::..|  .:|.||..    ..::||
  Fly   149 ------------PASSG--------------------YHSDNEDS--QSAASPKP----VEETMW 175

Mouse   278 RPW 280
            |||
  Fly   176 RPW 178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hes1	NP_032261.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		9/25 (36%)
		HLH	32..95	CDD:238036	21/62 (34%)
		Hairy_orange	110..148	CDD:284859	6/37 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..204		4/45 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..282		9/25 (36%)
		WRPW motif	277..280		2/2 (100%)
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	19/53 (36%)
		ORANGE	87..131	CDD:128787	7/46 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840