Protein Alignment Hes1 and E(spl)m3-HLH

DIOPT Version :9

• Sequence 1: NP_032261.1
• Gene: Hes1 / 15205
• MGIID: 104853
• Length: 282
• Species: Mus musculus
• Sequence 2: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Alignment Length: 262
• Identity: 68/262 - (25%)
• Similarity: 109/262 - (41%)
• Gaps: 61/262 - (23%)

Mouse    33 EHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNL-QRAQM 96
            ::||..||::|::||||||:.|..||.|:::.|:::....::||||||||:||.|:|.| ||..:
  Fly    10 QYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGL 74

Mouse    97 ----------TAALSTDPSVLGKYRAGFSECMNEVTRFL---STCEGVNTEVRTRLLGHLANCMT 148
                      :...||..:.:..:|:|:....:::|:.|   ...:.:..::...|...|....|
  Fly    75 SLQGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRLIELQT 139

Mouse   149 QINAMTYPGQAHPALQAPPPPPPSGPAGPQHAPFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAGE 213
            |:.......|.|...|.   |..||...             .|:.||..|...:|
  Fly   140 QLLQQQQQQQQHQQQQI---PQSSGRLA-------------FPLLGGYGPAAAAA---------- 178

Mouse   214 AAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTSDSMWR 278
                                .|...:|..|...:...||..|.::...| |.||..|..|:.:||
  Fly   179 --------------------AISYSSFLTSKDELIDVTSVDGNALSETA-SVSSQESGASEPVWR 222

Mouse   279 PW 280
            ||
  Fly   223 PW 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hes1	NP_032261.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		4/10 (40%)
		HLH	32..95	CDD:238036	31/62 (50%)
		Hairy_orange	110..148	CDD:284859	6/40 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..204		10/45 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..282		10/25 (40%)
		WRPW motif	277..280		2/2 (100%)
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	29/58 (50%)
		ORANGE	96..136	CDD:128787	6/39 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840