Protein Alignment ADRA2C and Oamb

DIOPT Version :9

• Sequence 1: NP_000674.2
• Gene: ADRA2C / 152
• HGNCID: 283
• Length: 462
• Species: Homo sapiens
• Sequence 2: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Alignment Length: 611
• Identity: 159/611 - (26%)
• Similarity: 232/611 - (37%)
• Gaps: 231/611 - (37%)

Human    39 WGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATL 103
            |..|....|       .||:.|:.|..:.||.||:.||..|..||:..|.|:|:||.||:||...
  Fly    15 WTEPANLIS-------LAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLA 72

Human   104 VMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRV 168
            |:|||...|:...|.||.:||.::||:||..||:||::|||||||||.:||:.|.|....:.::.
  Fly    73 VLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKA 137

Human   169 KATIVAVWLISAVISFPPLV--------------------------------------------- 188
            |:.|..:|::|..|.|||||
  Fly   138 KSLIAGIWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEA 202

Human   189 SLYRQP----DGAAY-------------------------------------------------- 199
            ||...|    :|.||
  Fly   203 SLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDL 267

Human   200 --------PQ---------CGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLS-- 245
                    ||         |.|.::..|:|.|.:|||:.|..:|...|.||||.|...||.::
  Fly   268 LNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQG 332

Human   246 ---------------EKRAPV------------------------------GPDGAS-------- 257
                           |:|..:                              .|:..|
  Fly   333 FKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLH 397

Human   258 -----------PTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGAL------RRGG 305
                       |::|| :...||.|:.||                 |||:...||      ...|
  Fly   398 HHDKIKISVSYPSSEN-ISELAGHGDVGH-----------------ERRQSGNALFAVHYNGTNG 444

Human   306 RR-------RAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRA 363
            |.       |...:.|...:.....|.|..|.....::.|...|...||.:::.:     .||..
  Fly   445 RESTESQLYRQQQQHGVASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKM-----GRRNI 504

Human   364 RSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYC 428
            ::.|.|.::    |.:....||:::|:|:.||.|||..|.:...|:: |..| .||...||:|||
  Fly   505 KAQVKRFRM----ETKAAKTLAIIVGMFIFCWCPFFTMYIIRPFCQD-CVDP-LLFSVLFWLGYC 563

Human   429 NSSLNPVIYTVFNQDFRRSFKHILFR 454
            ||::||:||.:|::|||.:||.|:.|
  Fly   564 NSAVNPMIYALFSKDFRFAFKRIICR 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADRA2C	NP_000674.2	7tmA_alpha2C_AR	60..448	CDD:320446	150/582 (26%)
		TM helix 2	86..112	CDD:320446	13/25 (52%)
		TM helix 3	124..154	CDD:320446	18/29 (62%)
		TM helix 4	166..189	CDD:320446	10/67 (15%)
		TM helix 5	207..236	CDD:320446	12/28 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..347		26/162 (16%)
		TM helix 6	375..405	CDD:320446	11/29 (38%)
		TM helix 7	416..441	CDD:320446	13/24 (54%)
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	56/124 (45%)
		7tm_1	37..>181	CDD:278431	59/143 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870