DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hdac5 and HDAC6

DIOPT Version :9

Sequence 1:	XP_017169770.1	Gene:	Hdac5 / 15184	MGIID:	1333784	Length:	1133	Species:	Mus musculus
Sequence 2:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster

Alignment Length:	1105	Identity:	280/1105 - (25%)
Similarity:	431/1105 - (39%)	Gaps:	312/1105 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse   133 QKHLKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRL 197
            :|..|....:|.|||       |.|..                :|:|:....:.::  |::   .
  Fly    56 RKSNKPNAALLEAKR-------RARNN----------------MLKNQGCGSQESV--TDI---F 92

Mouse   198 QEFLLSKS--KEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLP--------- 251
            |..:.|||  ::||....:.|:.||...|...|                   |:.|
  Fly    93 QNAVNSKSLVRKPTALIYDESMSQHCCLWDKEH-------------------YECPERFTRVLER 138

Mouse   252 --LLGPYDSRDDFPLRKTASEPNLKVRS-----RLKQKVA---ERRSSPLLRRKDGTVI--STFK 304
              .|...:...:.|.|....:..|::.:     |||:...   :.|...|..|.|...|  |||:
  Fly   139 CRELNLTERCLELPSRSATKDEILRLHTEEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFE 203

Mouse   305 KRAVEITGTGPGVSSVCNSAPGSGPSS-----PNSSHSTIAE-NG--FTGSVPNIPTEMIPQH-- 359
               :.:..:|..:..|.:...|...:.     |...|:..|| ||  |..:|.......:..|
  Fly   204 ---LSLLASGSTIELVDHLVAGKAQNGMAIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVHKL 265

Mouse   360 -RALPLD-----SSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQS-- 416
             |.|.:|     ....|...|..|.:...|:.       ...|.:..|.|   .|::..|:.|
  Fly   266 QRILIIDYDVHHGQGTQRFFYNDPRVVYFSIH-------RFEHGSFWPHL---HESDYHAIGSGA 320

Mouse   417 ---------LRQGGTLTGKFMSTSSIPGCLLGVAL----------------------EGDTSPHG 450
                     |...|...|.:::.  ....||.|||                      |.:.:|..
  Fly   321 GTGYNFNVPLNATGMTNGDYLAI--FQQLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPAC 383

Mouse   451 HASLLQHVLLLEQARQQSTLIAVPLHGQSPLVT-GERVATSMRTV--GKLPRHRPLSRTQSSPLP 512
            :..||..:|.|..||     :||.|.|...|.: .|..|.::|::  ...|   ||..|...|..
  Fly   384 YPHLLNPLLRLADAR-----VAVVLEGGYCLDSLAEGAALTLRSLLGDPCP---PLVETVPLPRA 440

Mouse   513 QSPQALQQ-LVMQQQHQQFLEKQKQQQMQLGKILTKTGELSRQPTTHPEETEEELTEQQEALLGE 576
            :..|||.. :.:.:.|.:.|:.|
  Fly   441 ELAQALLSCIAVHRPHWRCLQLQ------------------------------------------ 463

Mouse   577 GALTIPREGSTESESTQEDLEEEEEEEEEEEEDCIQVKDEDGE-----------SGP---DEGPD 627
                                         :..||::::|.|.|           .||   |..|.
  Fly   464 -----------------------------QTYDCVELQDRDKEEDLHTVLRHWIGGPPPMDRYPT 499

Mouse   628 LEES-SAGYKKLFADAQQLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGSMKSPTDQPTVVKHL 691
            .:.: ....:||.::|.:||.|                  |.::..:.|.
  Fly   500 RDTAIPLPPEKLTSNAARLQVL------------------RAETKLSVPS--------------- 531

Mouse   692 FTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLGKCERIRGRKATLDEIQTVHS 756
            |.....||..||.| |...:|. |||...|||.|.....:.|||.:.:::..|.||.||:...|:
  Fly   532 FKVCYAYDAQMLLH-CNLNDTG-HPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHT 594

Mouse   757 EYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAMLPCGGIGVDSDTVWNEMH----SSSAVRMAVG 817
            ..|....            ::|||...::::          |:..::|.::    :.....:|.|
  Fly   595 RAHVNTV------------RRLLGREPKELH----------DAAGIYNSVYLHPRTFDCATLAAG 637

Mouse   818 CLVELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLSVGKVLIVDWDI 882
            .:::....|..||.::|...:||||||||:....|||.||:|||.|:...:...:.:|||||||:
  Fly   638 LVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDV 702

Mouse   883 HHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGD 945
            |||||||..|.::|.|||||||||::|:|||  ..|..:.||.|.|.|:|||:.|.   ...:||
  Fly   703 HHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWN---KKGMGD 764

Mouse   946 VEYLTAFRTVVMPIAQEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVV 1010
            :||..||:.::||||.||:|.:|||||||||..|  .||||..|||..:|.||..|..||.||::
  Fly   765 LEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIG--DPLGGCKVTAEGYGMLTHWLSALASGRII 827

Mouse  1011 LALEGGHDLTAICDASEACVSALLS--VELQPLDEAVLQQKPSV---NAVATLEKVIEIQSKHWS 1070
            :.||||:::.:|..|...|...||.  |....|....||:.|:|   :.|.:|::.:::|..||.
  Fly   828 VCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWR 892

Mouse  1071 CVQRFAAGLGCSLREAQTGEKEEAETVSA-MALLSVGAEQAQAVATQEHSPRP---AEEPMEQEP 1131
            .::.....|.   |:...||....:.::| :..|::..:.|.|.|......||   .|.|...:|
  Fly   893 SLEFVGRRLP---RDPVVGENNNEDFLTASLRHLNISNDDATAAAGGLAGDRPDCGDERPSGSKP 954

Mouse 1132 1131
Fly 955 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hdac5	XP_017169770.1	ClassIIa_HDAC_Gln-rich-N	87..174	CDD:391182	8/40 (20%)
Hdac5	XP_017169770.1	HDAC5	690..1109	CDD:212531	156/430 (36%)
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	76/379 (20%)
		HDAC6-dom2	538..895	CDD:212527	149/385 (39%)
		zf-UBP	1007..1069	CDD:280334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750