Protein Alignment PPM1L and Nil

DIOPT Version :10

• Sequence 1: NP_640338.2
• Gene: PPM1L / 151742
• HGNCID: 16381
• Length: 360
• Species: Homo sapiens
• Sequence 2: NP_651472.2
• Gene: Nil / 43185
• FlyBaseID: FBgn0039421
• Length: 371
• Species: Drosophila melanogaster
• Alignment Length: 312
• Identity: 91/312 - (29%)
• Similarity: 155/312 - (49%)
• Gaps: 49/312 - (15%)

Human    71 RLGGLDVLEAEFSKTWEFKNH----NVAVYSIQGRRDHMEDRFEVLTDLANKTHP----SIFGIF 127
            ::||.  ||...::....:.|    ...|.|:||.|..|||.......|.:   |    |.|.:|
  Fly     4 KMGGF--LEKPETEKQAQEGHGNGLRYCVSSMQGWRLEMEDSHSAACRLKD---PFATWSYFAVF 63

Human   128 DGHGGET----AAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLTVSY 188
            |||.|..    .||::.|.:.|:     :.:.|.|      |:..:.:..|.:|.:|.:   :.:
  Fly    64 DGHAGSQISLHCAEHLMSTILES-----ESFSKHK------YEAGIREGFLQLDEDMRK---LYH 114

Human   189 D-EAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN 252
            | :.|:|.:...:|...:.:.|.||||.|: .::|.|:..:.||||:..||::||:.|||.:...
  Fly   115 DQQGGSTAICVFVSPDKIYLVNCGDSRAVI-SRNGAAVISTIDHKPFSPKEQERIQNAGGSVMIK 178

Human   253 GSWRVQGILAMSRSLGDYPLKN-------LNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSN 310
               |:.|.||:||:.|||..||       ..:|.|:|||:..:..: ..||:::|.||:||..::
  Fly   179 ---RINGTLAVSRAFGDYDFKNDGSKSPVDQMVSPEPDIIVCNRSE-HDEFIVVACDGIWDVMTS 239

Human   311 EEAVRFIKERL----DEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTE 358
            .|...||:.||    |.|.. ..|::....::|..||:|::::....:.|.:
  Fly   240 SEVCEFIRSRLLVTYDLPMI-VNSVLDICLHKGSRDNMTLLLLLLPGAPKVD 290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPM1L	NP_640338.2	PP2Cc	93..351	CDD:238083	85/277 (31%)
Nil	NP_651472.2	PP2Cc	27..277	CDD:238083	84/272 (31%)
		PP2C_C	284..355	CDD:429684	1/7 (14%)