DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hcn1 and CG42260

DIOPT Version :9

Sequence 1:	NP_034538.2	Gene:	Hcn1 / 15165	MGIID:	1096392	Length:	910	Species:	Mus musculus
Sequence 2:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster

Alignment Length:	936	Identity:	215/936 - (22%)
Similarity:	350/936 - (37%)	Gaps:	263/936 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse    22 PSKAPATGPVAADKRLGTPPGGGAAGKEHGNSVCFKVDGGGGEEPA--GSFEDAEGPRRQYGFMQ 84
            ||:....||       |.|.||......||.:     ..|||..|.  |.....:.|||.
  Fly   508 PSQGGPGGP-------GPPHGGHPHHPHHGGA-----GSGGGSGPGSHGGQPHHQKPRRT----- 555

Mouse    85 RQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAG---FWIIHPYSDFRFYWDLIMLIMMVGNL 146
                               .||:.      |..||.   .::..|.....:||.:::.:..:.|.
  Fly   556 -------------------ASQRI------RAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNF 595

Mouse   147 VIIPVGITF--FTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKM--NYL 207
            .:|.....|  ...:|...|...:..||.::|:|::.:||||.: ||.   :|....:|:  :|:
  Fly   596 WVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTGYL-EDG---VLQTDALKLRTHYM 656

Mouse   208 KSW-FVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWE 271
            .|. |.:|.:..:|:|:::|                  .:.|..||...||:::.|...::.:.|
  Fly   657 NSTIFYIDCLCLLPLDFLYL------------------SIGFNSILRSFRLVKIYRFWAFMDRTE 703

Mouse   272 EIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWG----K 332
            .  |..|   ..:.|...||..:|::.||:|||..::.....|....||     .:||..    |
  Fly   704 R--HTNY---PNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWV-----YHDSESADVVK 758

Mouse   333 QYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQ 397
            ||..:.:.....:..|| ....|.|..:....:|.::.|...:|..:||...::.|:.::|:::|
  Fly   759 QYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQ 822

Mouse   398 EKYKQVEQYMSFHKLPADMRQKIHDYYEHRY-QGKIFDEENILSELNDPLREEI-VNFNCRKLVA 460
            .|...|:.||...::|..::.|:..::::.: ..|..|||..:|.|.|.|:.|| :|.:...| .
  Fly   823 AKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTL-K 886

Mouse   461 TMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEM--KLTD 523
            .:.:|.|.:..|:..::.:||..:|.|||||.|:|.|||:||.:..|...|:..:.|.:  .|..
  Fly   887 RVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKA 951

Mouse   524 GSYFGEICLLTKG----RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIG 584
            |||||||.:|..|    |||||||:..|..|:.||..:..:||:|||..|...|::|:.|
  Fly   952 GSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKR----- 1011

Mouse   585 KKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIPPINYPQMTALNCTSSTTTPTSRM 649
                  |:|::|                          ..:..:.|..:.|:.
  Fly  1012 ------LEKYKK--------------------------APLEKVKYFNVVAMG------------ 1032

Mouse   650 RTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTT--AVCSPPIQSPLATRTFHYASPT 712
            |.||.|                         .::..|..|:  .:..||              .|
  Fly  1033 RCQSTP-------------------------GLVESCGRTSLEEMWLPP--------------AT 1058

Mouse   713 ASQLSLMQQPQQQLPQSQVQQTQTQTQQQQQQQQQQQQQQQQQQQQQQ---------QQQQQQQQ 768
            |...|||...|             ..|||.|..|||..:|:..|...|         ..:..:..
  Fly  1059 AGASSLMHHHQ-------------ALQQQHQASQQQPHRQESTQTSSQTHGYSPRSYADRLARAT 1110

Mouse   769 QQQQQQQPQTPGS-------STPKNEVHKSTQALHNTNLTKE-----------------VRPLSA 809
            ...:...|...||       :|..:.:...:|..|..::...                 ..||..
  Fly  1111 DSPRSVSPSAHGSEERPRSRTTSHHSIRPQSQPSHTGHICDSSSQLECYGAGVGGAGGGTTPLLG 1175

Mouse   810 SQPSLPHEVSTLISRPHPTVGES-----------------LASIPQPVAAVHSTGLQAGSRSTVP 857
            |...|..|:..|..|.|....|:                 ||.|...:..|.||.      |..|
  Fly  1176 SHEVLEDEIKRLRERLHTVESENQALNTKLSQQQWDLENRLAEIEMQICGVSSTS------SVDP 1234

Mouse   858 QRVT--LFRQMSS----GAIPPNRGV 877
            :..|  |.|...|    |::.|::.:
  Fly  1235 ENETEELERNRESIIXHGSVLPHQAI 1260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcn1	NP_034538.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		15/54 (28%)
		Ion_trans_N	87..129	CDD:285597	6/44 (14%)
		Ion_trans	149..394	CDD:278921	59/253 (23%)
		Selectivity filter. /evidence=ECO:0000305\|PubMed:12089064	347..351		2/3 (67%)
		Crp	458..>593	CDD:223736	53/140 (38%)
		CAP_ED	464..572	CDD:237999	48/113 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..681		5/46 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	771..791		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..910		3/17 (18%)
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	62/270 (23%)
		CAP_ED	890..1004	CDD:237999	48/113 (42%)
		DUF4655	1084..>1154	CDD:317882	9/69 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3583
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960