DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Serpind1 and Spn42Dd

DIOPT Version :9

Sequence 1:	NP_001317976.1	Gene:	Serpind1 / 15160	MGIID:	96051	Length:	478	Species:	Mus musculus
Sequence 2:	NP_001163067.1	Gene:	Spn42Dd / 49808	FlyBaseID:	FBgn0028988	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	375	Identity:	106/375 - (28%)
Similarity:	190/375 - (50%)	Gaps:	38/375 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse   116 LYRVLKDQATTSDNLFIAPVGISTAMGMISLGLRGETHEEVHSVLHF--RDFVNASSKYEVTTIH 178
            :|::| .::.|:.||.::||.|.|.:.|:.:|..|.|.:|:.|.|..  .|....:::|..
  Fly    21 IYQLL-SKSHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQSALGLPSEDKEAVAARYGA---- 80

Mouse   179 NLFRKLTHRLFRRNFGYTLRSVNGLYIQKQFPIREDFKAAMREFYFAEAQEANFPD-PAFISKAN 242
                 |.:.|..:..|..|:..|.:|:..|:.:.:::..|:||.:.:||:..:..: |....:.|
  Fly    81 -----LLNDLQGQEEGPILKLANRIYVNDQYSLNQNYNLAVREPFKSEAESISLTNGPVAAERIN 140

Mouse   243 NHILKLTKGLIKEALENIDPAT-----QMLILNCIYFKGTWVNKFPVEMTHNHNFRLNEREVVKV 302
            ..:|..|.|.||..   |||.:     :.|::|.|||||.|.:||....|....|::...:.|.|
  Fly   141 QWVLDQTSGKIKGM---IDPGSMTSDVKALLVNAIYFKGQWESKFDPAKTRASTFQVTANKSVPV 202

Mouse   303 SMMQTKGNFLAANDQELDCDILQLEYV-GGISMLIVVPRKLSGMKTLEAQLTPQVVERWQKSMTN 366
            .||...|.|.|...::||..:::|.|: ..:||.|.:||::.|:..||.::.     .:.:.:..
  Fly   203 QMMAQMGTFRANYFRDLDAQVIELPYLNSNLSMTIFLPREVEGLSALEEKIV-----GFARPLVA 262

Mouse   367 RTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSGISDQRIA--IDLFKHQSTITVNEEGT 429
            :...:.|||||:|....|.|.|:.:||.:||....::||:...:..  :....|::.:.|||||.
  Fly   263 KEVYLKLPKFKIEFRDELKETLEKLGIRELFTDKSDLSGLFADKSGGKVSQVSHKAFLEVNEEGA 327

Mouse   430 QAAAVTTVGFMPLSTQVRFT----VDRPFLFLVYEHRTSCLLFMGKVTNP 475
            :||..|:|.   ::.:..|:    .|.||.|::.:..|  :.|.|:|.:|
  Fly   328 EAAGATSVA---VTNRAGFSTFLMADHPFAFVIRDANT--IYFQGRVVSP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Serpind1	NP_001317976.1	HCII	43..476	CDD:239002	106/375 (28%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	54..78
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	171..191		3/19 (16%)
Spn42Dd	NP_001163067.1	SERPIN	16..369	CDD:238101	104/370 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020