Protein Alignment GPR155 and anchor

DIOPT Version :10

• Sequence 1: NP_689742.4
• Gene: GPR155 / 151556
• HGNCID: 22951
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_001261995.1
• Gene: anchor / 39965
• FlyBaseID: FBgn0036741
• Length: 957
• Species: Drosophila melanogaster
• Alignment Length: 961
• Identity: 315/961 - (32%)
• Similarity: 499/961 - (51%)
• Gaps: 130/961 - (13%)

Human     1 MNSNLPAENLTIAVN-------MTKTLPTAVTHGFNSTN-DPPSMSITRLFPALLECFGIVLCGY 57
            |:|::...:..||.:       :|.|:.:::.:|..:.. |...:|:...:|||::||||::|||
  Fly     1 MDSSMYYASQRIAASTEANVRVITSTMASSLANGTATPRADDGGVSMNNFYPALVQCFGIIICGY 65

Human    58 IAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWSFLYSILIAKASVFFIVCVLTL 122
            ||||..:|::.:.||||.||..||||:|:|.::|.||:|.|:||||.::|::||.|||.|.:::|
  Fly    66 IAGRFKIISNAETKGLGTFVGTFALPSLIFLSLVELNWSAVNWSFLLAMLVSKAVVFFAVLIISL 130

Human   123 LVASPDSRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIF 187
            |||.| ..:::.||..||.|||||||:|||||.|||:..:|||..|:||:|||||.:|||:|.:.
  Fly   131 LVARP-LNYARGGLMAIFCTQSNDFAIGYPIVMALYKDVHPEYASYLYLMAPISLAILNPVGLVL 194

Human   188 CEIQK-WKDTQNASQN----------------------KIKIVGLGLLRVLQNPIVFMVFIGIAF 229
            .||.| .|:.::.::|                      :..:|...|:.:..||::.|..:|:|.
  Fly   195 MEISKIIKNKEDVTRNPPLCPETCPAEQMSKRNRCLGERSILVFNTLIALFFNPLLLMTLLGVAG 259

Human   230 NFILDRKVPVYVENFLDGLGNSFSGSALFYLGLTMVGKIKRLKKS-AFVVLILLITAKLLVLPLL 293
            .|:....:|..|.:.|..||.|||.:|||.|||.:||.....:|| .|::..:||..|:|||||:
  Fly   260 GFLFPNGLPEMVSSTLRVLGQSFSATALFLLGLKIVGGTGSERKSIGFLLPGVLILVKILVLPLV 324

Human   294 CREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIM 358
            .|:.|.::..|.:..:.|.||.:.||||.||.|||..:.|||:|||||::...||..||:|||:|
  Fly   325 IRQTVNIMQSGQNFNDTTELSTFGFLYGTFPAAPGAFVIATQYNMEVELVARSMVFCTFISAPLM 389

Human   359 YVSAWLLTFPTMDPKPLAYAIQNVSFDISIVSLISLIWSLAILLLSKKYKQLPHMLTTNLLIAQS 423
            ::||.:::...:.|....:.:...|||||:....:....||:|:::|::|::|..:|..|:::|.
  Fly   390 FISAKMISLTNLKPLDYLHELDAFSFDISVAGAAACCIMLALLIVTKRFKRMPQRITFCLVLSQL 454

Human   424 IVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKKRERVQI----PVGII 484
            :.|.|:::|:.::..:.....|.|:|.....|||.||||||||||..|:.|....:    |  .:
  Fly   455 MCCIGVILWSKMEHVHRWPLYLQFLLFNIGTYSTRLWTGLLAISLLFLQCRSLCFVLKLWP--YM 517

Human   485 IISGWGIPALLVGVLLITGKH--NGDSIDSAFFYGKEQ-MITTAVTLFCSILIAGISLMCMNQTA 546
            ::..||:||:|..:|:....:  :|:..:.:|.||..| .|:..:.:.|.|:..|..::......
  Fly   518 LVFAWGVPAVLSALLIAFDSNVMSGEKHNPSFQYGNAQAAISVFMLVMCFIVTVGCLVLHQRYKK 582

Human   547 QAGSYEGF---------DQSQSHKVVEPGN---------------TAFEESPAPVNEPELFTSSI 587
            :...|..:         :.|..|..:...|               ||...|.:...|.....:.:
  Fly   583 RYEKYMTYSRELSNPESESSDLHSTISTTNLLSHTDQSSIRQSVRTASYSSSSDDEEMIPTAAGL 647

Human   588 PETSCCS-------------CSMGNGELHCPSIEPIANTSTSEPVIPSFE--------------- 624
            | ||..:             |..|||.. |....|::|:||:..|:...|
  Fly   648 P-TSRSNGAASGGAGSGGGGCGSGNGTC-CSGGAPVSNSSTTSTVVVDIEDLLNRTRQRASGANN 710

Human   625 ---------------KNNHCVSRCN------SQSC--ILAQEEEQYLQ----------SGDQQLT 656
                           :|..|.|..|      .|||  |:.:.|:|..:          :.:.|..
  Fly   711 KDLNKIESAPATEEIRNQMCSSSFNCGPSTSRQSCQTIIERYEDQNRRGLEPLEHPSDADEHQTL 775

Human   657 RHVLLCLLLIIGLFANLSSCLWWLFNQEPGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILP 721
            :|.:|.:.|:..:|..|:..:|.|..:....:|:||.|..|..|||||.|...:|..|...:::|
  Fly   776 KHTVLLITLLCSMFVGLAVSIWTLVMEGMSGIYLELSFLDAFLNFGQGLIVLAVFITDIGELLMP 840

Human   722 FKRRLEFLWNNKDTAE-NRDSPVSEEIKMTCQQFIHYHRDLCIRNIVKERRCGAKTSAGTFCGCD 785
            ..:....||...:... ...|.|..|.|..|:||.::|.:.|.::|.|:||...:.....|.|.:
  Fly   841 VVKLWRKLWYGANVVSLPHWSNVRPETKHICEQFRNHHLENCKKDIAKDRRWRIRVYRRVFYGTE 905

Human   786 LVSWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQK 836
            .|||||||||:.||.|||.|...||.|.|::||.|.|.|.|:.|.|.|..:
  Fly   906 FVSWLIEVGLSKDRMEAVHYARHLVDGRVLRHINNVYHFEDKLLLYNFCSR 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPR155	NP_689742.4	PIN-like transporter. /evidence=ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X	1..370		164/400 (41%)
		YfdV	42..366	CDD:440443	155/347 (45%)
		GPCR. /evidence=ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X	380..717		104/428 (24%)
		DEP_GPR155	751..833	CDD:239890	38/81 (47%)
anchor	NP_001261995.1	YfdV	47..391	CDD:440443	153/344 (44%)
		7tm_GPCRs	429..>536	CDD:475119	37/108 (34%)
		TM helix 2	442..460	CDD:410628	5/17 (29%)
		TM helix 3	475..497	CDD:410628	12/21 (57%)
		TM helix 4	516..532	CDD:410628	5/15 (33%)
		DEP_GPR155	871..953	CDD:239890	38/81 (47%)