DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTSV and CG12163

DIOPT Version :9

Sequence 1:	NP_001188504.1	Gene:	CTSV / 1515	HGNCID:	2538	Length:	334	Species:	Homo sapiens
Sequence 2:	NP_730901.1	Gene:	CG12163 / 40628	FlyBaseID:	FBgn0260462	Length:	614	Species:	Drosophila melanogaster

Alignment Length:	320	Identity:	125/320 - (39%)
Similarity:	181/320 - (56%)	Gaps:	19/320 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    20 KFDQNLDTKWYQWKATH-RRLYGANEEGWRRAVWEKNMKMI-ELHNGEYSQGKHGFTMAMNAFGD 82
            :||: :|..:|:::... ||.....|...|..::.:|:|.| ||:..|....|:|.|    .|.|
  Fly   300 RFDK-VDHLFYKFQVRFGRRYVSTAERQMRLRIFRQNLKTIEELNANEMGSAKYGIT----EFAD 359

Human    83 MTNEEFRQMMGCFRNQ--KFRKGKVFREPLFL-DLPKSVDWRKKGYVTPVKNQKQCGSCWAFSAT 144
            ||:.|:::..|.::..  |...|.....|.:. :|||..|||:|..||.||||..||||||||.|
  Fly   360 MTSSEYKERTGLWQRDEAKATGGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSCWAFSVT 424

Human   145 GALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDE 209
            |.:||....|||:|...|||.|:||...  :..||||.|..|::.:|:.|||:.|..|||.|...
  Fly   425 GNIEGLYAVKTGELKEFSEQELLDCDTT--DSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAKKN 487

Human   210 ICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIY--FEPDCSS 272
            .|.:....|.....||..:..|.|.|:.:.:...||||:.::|  ::.|||:.|:.  ::..||.
  Fly   488 QCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINA--NAMQFYRGGVSHPWKALCSK 550

Human   273 KNLDHGVLVVGYGF-EGANSNNS-KYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAAS 330
            |||||||||||||. :..|.:.: .||:|||||||.||..||.::.:. :|.||::..|:
  Fly   551 KNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRG-DNTCGVSEMAT 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTSV	NP_001188504.1	Inhibitor_I29	29..87	CDD:214853	18/59 (31%)
CTSV	NP_001188504.1	Peptidase_C1	114..332	CDD:306594	99/221 (45%)
CG12163	NP_730901.1	CY	194..272	CDD:298856
		Inhibitor_I29	308..365	CDD:285458	18/60 (30%)
		Peptidase_C1A	395..611	CDD:239068	98/220 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149682
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740