Protein Alignment CTSV and CtsK2

DIOPT Version :10

• Sequence 1: NP_001324.2
• Gene: CTSV / 1515
• HGNCID: 2538
• Length: 334
• Species: Homo sapiens
• Sequence 2: NP_725686.1
• Gene: CtsK2 / 36973
• FlyBaseID: FBgn0034229
• Length: 420
• Species: Drosophila melanogaster
• Alignment Length: 332
• Identity: 129/332 - (38%)
• Similarity: 179/332 - (53%)
• Gaps: 18/332 - (5%)

Human    14 IASAVPKFD--QNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMA 76
            ||.||||..  .|:.........:.:....|.:.......:.....::|..|..::||.|.|..|
  Fly    96 IAKAVPKVPLLSNVQDFGDFLSQSGKTYLSAADRALHEGAFASTKNLVEAGNAAFAQGVHTFKQA 160

Human    77 MNAFGDMTNEEF-RQMMGCFRNQKFRKG-----KVFREPLFLDLPKSVDWRKKGYVTPVKNQKQC 135
            :|||.|:|:.|| .|:.|..|:.:.:..     |:...|. ..:|.:.|||:.|.|||||.|..|
  Fly   161 VNAFADLTHSEFLSQLTGLKRSPEAKARAAASLKLVNLPA-KPIPDAFDWREHGGVTPVKFQGTC 224

Human   136 GSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQ--GNQGCNGGFMARAFQYVKE-NGGLD 197
            ||||||:.|||:||..|||||.|.:|||||||||...:  |..||:|||...||.::.| ..|:.
  Fly   225 GSCWAFATTGAIEGHTFRKTGSLPNLSEQNLVDCGPVEDFGLNGCDGGFQEAAFCFIDEVQKGVS 289

Human   198 SEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKS 262
            .|.:|||:.....|||....|.|...||..:.|..|:.|.|.|||:||::.::: |..:.:.|..
  Fly   290 QEGAYPYIDNKGTCKYDGSKSGATLQGFAAIPPKDEEQLKKVVATLGPVACSVN-GLETLKNYAG 353

Human   263 GIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIAT 327
            |||.:.:|:....:|.:||||||.|    ....||:|||||...||..||.::.:.| |:|.||.
  Fly   354 GIYNDDECNKGEPNHSILVVGYGSE----KGQDYWIVKNSWDDTWGEKGYFRLPRGK-NYCFIAE 413

Human   328 AASYPNV 334
            ..|||.|
  Fly   414 ECSYPVV 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSV	NP_001324.2	Inhibitor_I29	29..87	CDD:214853	13/57 (23%)
		Peptidase_C1	114..332	CDD:425470	99/220 (45%)
CtsK2	NP_725686.1	Inhibitor_I29	112..172	CDD:462410	13/59 (22%)
		Peptidase_C1A	204..418	CDD:239068	99/219 (45%)