Protein Alignment CTSV and CtsB1

DIOPT Version :9

• Sequence 1: NP_001188504.1
• Gene: CTSV / 1515
• HGNCID: 2538
• Length: 334
• Species: Homo sapiens
• Sequence 2: NP_001259536.2
• Gene: CtsB1 / 32341
• FlyBaseID: FBgn0030521
• Length: 340
• Species: Drosophila melanogaster
• Alignment Length: 308
• Identity: 85/308 - (27%)
• Similarity: 136/308 - (44%)
• Gaps: 62/308 - (20%)

Human    73 FTMAMNAFGDMTNEEFRQMMGCFRN-QKFR---KGKVFREPLFL----DLPKSVDWRKKGYVTP- 128
            :|:..|....:|....|::||...: .||.   |.:|..: |::    :||:..|.||:....|
  Fly    39 WTVGRNFDASVTEGHIRRLMGVHPDAHKFALPDKREVLGD-LYVNSVDELPEEFDSRKQWPNCPT 102

Human   129 ---VKNQKQCGSCWAFSATGALEGQMFRKTGKLVS--LSEQNLVDCSRPQGNQGCNGGFMARAFQ 188
               :::|..|||||||.|..|:..::...:|..|:  .|..:||.|....| .||||||...|:.
  Fly   103 IGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHTCG-FGCNGGFPGAAWS 166

Human   189 Y-----VKENGGLDSEES-YPYVAVDEI--CKYR--------------PENSVANDTGFTV-VAP 230
            |     :...|...|.:. .||    ||  |::.              |:.|....:|:|| .|.
  Fly   167 YWTRKGIVSGGPYGSNQGCRPY----EISPCEHHVNGTRPPCAHGGRTPKCSHVCQSGYTVDYAK 227

Human   231 GKE------------KALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNL-DHGVLVV 282
            .|.            :.:.:.:.|.||:..|... :.....||.|:|...  ..|.| .|.:.::
  Fly   228 DKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTV-YEDLILYKDGVYQHE--HGKELGGHAIRIL 289

Human   283 GYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAAS 330
            |:|..|  .....|||:.|||..:||.:|:.:|.:.: :||||.::.|
  Fly   290 GWGVWG--EEKIPYWLIGNSWNTDWGDHGFFRILRGQ-DHCGIESSIS 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSV	NP_001188504.1	Inhibitor_I29	29..87	CDD:214853	3/13 (23%)
		Peptidase_C1	114..332	CDD:306594	74/259 (29%)
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	6/24 (25%)
		Peptidase_C1A_CathepsinB	88..336	CDD:239111	73/258 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149677
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850