Protein Alignment SLC16A14 and Sln

DIOPT Version :10

• Sequence 1: NP_689740.2
• Gene: SLC16A14 / 151473
• HGNCID: 26417
• Length: 510
• Species: Homo sapiens
• Sequence 2: NP_610706.1
• Gene: Sln / 36263
• FlyBaseID: FBgn0033657
• Length: 855
• Species: Drosophila melanogaster
• Alignment Length: 618
• Identity: 139/618 - (22%)
• Similarity: 246/618 - (39%)
• Gaps: 159/618 - (25%)

Human    26 PNI---DGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTA-WVSSLSMGITLIV 86
            ||:   |||:.|.:|..:|.|...:.|...:.|||.||.:|.|..|....| |:.::...:.|::
  Fly   221 PNVEPPDGGYGWFIVFGAFSVQFWVAGLVKSYGVLYVEIMETFPSSTATVASWIPAILSALCLVL 285

Human    87 GPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGR 151
            .|..........||....:||:..::|.:||.:|.::.:|.:||||..|:|.|::..|.:|:|.:
  Fly   286 APLSSALCQRFSCRTVVFVGGIFCAMGMILSYFATSLLHLLLTFGVLTGIGGGLSTTPGIVIVSQ 350

Human   152 YFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCVCGALMRPLSPGK 216
            ||.|.||||.|:..:||..|:|::.||:|:|....|:...:||.|...|::||...|.||:|...
  Fly   351 YFDKHRALANGICVSGTAAGSFILPVLIKHLAENCGFHGTILILGGCMLHVCVSATLYRPISAYT 415

Human   217 NPNDPGEKDVRGLPAHSTESVKSTG---QQGRTEEKDGGLGNE---------------------- 256
            :.:....::....|.:...:..:||   .....:..|.|.|:|
  Fly   416 DQDSGQGQEETAKPLNEDINPSTTGILTTSTYLDTCDVGAGHELSDKFIEHLFLEESKNHLNYYA 480

Human   257 --ETLCDLQAQECPDQAGHRKNMCA----LRILKTV--SWLTMRVRKGFED--W-YSGYFGTAS- 309
              :...|..|||..|:.   |::..    ::.:|.|  |.|...|.....|  | |..:.||.|
  Fly   481 SKQPAQDKSAQESDDEV---KDIIGETTFIKPMKKVRSSGLLHSVEDLSTDSTWVYRKHSGTDSN 542

Human   310 --------LFTNRMFVA------------------------------------------------ 318
                    :|.|...::
  Fly   543 RGSRRRRNVFANDEVISKIQAHLEKPLSPPSVVSRGLSKSMEIPTPVSNLSDLKQQPVEQAELGI 607

Human   319 ---------------------------------------FIFWALFAYSSFVI------------ 332
                                                   ::..:|....||::
  Fly   608 LDSQLVESIIDGDGHLAADEDDDDDEERGPRTCCERIEMYLDISLLQDPSFILMCLSVTLMSVGC 672

Human   333 PFI--HLP-EIVNL-YNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCISVWNVFLLANFTLV 393
            |::  :|| .:::: ||.||..   .|.:|.|::.:.|::.||.:.||........:.|......
  Fly   673 PYMLYYLPAHVISIGYNKSEAG---YLVAISAVLDLIGRLGLGWLCDLQLFDRKKTYTLCILGAG 734

Human   394 LSIFILPLMHTYAGLAVICALIGFSSG-YFSLMPVVTEDLVGIEHLANAYGIIICANGISALLGP 457
            .::..:|...|...:.:..|:.|...| ::.||||:..|:.|.:.::::||::.....|.|:..|
  Fly   735 CAVLTIPFAKTLVLVGLSAAVYGLCLGSWYVLMPVLLADVFGTDRISSSYGLVRMFQSIGAISVP 799

Human   458 PFAGWIYDITQKYDFSFYICGLLYMIGILFLLI 490
            |.||.:.|::..|:..||..|...::|...|::
  Fly   800 PLAGLMRDLSGDYEICFYCMGSCMVLGTTPLIV 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A14	NP_689740.2	MFS_MCT14	33..492	CDD:340987	134/608 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	214..255		5/43 (12%)
Sln	NP_610706.1	MFS_MCT_SLC16	231..>409	CDD:340910	60/177 (34%)
		MFS	<652..834	CDD:475125	45/184 (24%)