Protein Alignment SLC16A14 and chk

DIOPT Version :10

• Sequence 1: NP_689740.2
• Gene: SLC16A14 / 151473
• HGNCID: 26417
• Length: 510
• Species: Homo sapiens
• Sequence 2: NP_610230.3
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Alignment Length: 763
• Identity: 176/763 - (23%)
• Similarity: 279/763 - (36%)
• Gaps: 285/763 - (37%)

Human     9 GYDFEDGPKDKKTLK-PHPNIDGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLT 72
            |...:....:|||.| |    |||:.|::|.:|..|.::..|...:.|::|||.||.|.:|...|
  Fly   117 GDSIDSSSTEKKTPKMP----DGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKT 177

Human    73 AWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLG 137
            ||:|||...:.|::||.....::..|||:..|:||:|::.|:.||::..::..|.:|||:.:|||
  Fly   178 AWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLG 242

Human   138 SGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNL 202
            .|:.|:.|||.:..:|.|:|..|.|:..:|||.|||:...|..||...||||.|.||.|...||.
  Fly   243 LGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNA 307

Human   203 CVCGALMR--------------------------------------------------------- 210
            ||||||||
  Fly   308 CVCGALMRDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEAN 372

Human   211 -----PL-------------------------------------------SPGK----------- 216
                 ||                                           :|.:
  Fly   373 QQIDDPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAG 437

Human   217 ----------NPND--------------------------PGEKDVRG----------------- 228
                      :|:|                          |.||...|
  Fly   438 AYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQ 502

Human   229 --------------LPAHSTESVKSTGQQG--------RTEEKDGGLGNEETLCDLQAQE----- 266
                          :..|:|.|:.:....|        .:|:.......:||...|:...
  Fly   503 KHASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPT 567

Human   267 ---CPDQ------------------------------AGHRKNMCALRILKTVSWL--------- 289
               .|:|                              :.||.|:.....::..::|
  Fly   568 VIAIPEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNS 632

Human   290 ---------TMRVR------------------KGFED-WYSGYFGTA------SLFTNRMFVAFI 320
                     |.|.|                  |..|| ||..:..|.      |||.:..|..|.
  Fly   633 IHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFN 697

Human   321 FWALFAYSSFVIPFIHLPEIVN--LYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCISVWN 383
            ...||.:..|:||:::||:.:.  .|::|:..:   |.|.:.|....|.:.||.:.||..:::..
  Fly   698 LSTLFLFIWFIIPYLYLPDYMKQYKYDVSQSAE---LISDVGIAQTVGMIGLGYLGDLSWMNINI 759

Human   384 VFLLANFTLVLSIFILPLMHT-YAGLAVICALIGFS-SGYFSLMPVVTEDLVGIEHLANAYGIII 446
            .:.|.......|:|.:||:.| |.||.|:|.:.||: :..||..|.:...:|.::....|||:::
  Fly   760 CYSLCMLVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVL 824

Human   447 CANGISALLGPPFAGWIYDITQKYDFSFYICGL-LYMIGILFLLIQPC 493
            ...|:..:.|||.||.||:.|.::|.:||..|: :.:.|:...||:.|
  Fly   825 LVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFC 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A14	NP_689740.2	MFS_MCT14	33..492	CDD:340987	166/735 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	214..255		12/126 (10%)
chk	NP_610230.3	MFS_MCT_SLC16	138..>315	CDD:340910	74/176 (42%)
		MFS	<687..869	CDD:475125	55/184 (30%)