DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hc and Tep3

DIOPT Version :9

Sequence 1:XP_017171158.1 Gene:Hc / 15139 MGIID:96031 Length:1684 Species:Mus musculus
Sequence 2:NP_523507.2 Gene:Tep3 / 34045 FlyBaseID:FBgn0041181 Length:1469 Species:Drosophila melanogaster


Alignment Length:1671 Identity:369/1671 - (22%)
Similarity:644/1671 - (38%) Gaps:366/1671 - (21%)


- Green bases have known domain annotations that are detailed below.


Mouse    18 LVEAATLL------IYVISAPKILRVGSSENVVIQVHGYTEA--FDATLSLKSYPDKKVTFSSGY 74
            ||.|..|.      :|.|.||..||..|..:|.:.:|...|:  |...:...||.|.|.      
  Fly    16 LVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKT------ 74

Mouse    75 VNLSPEN----KFQNAALLTLQPNQVPREESPVSHVYLEVVSKHFSKSKKIPITYNNGILFIHTD 135
            |.|.|.:    .|:..||.|.:..........|.  :......|| :||:..:       .:.||
  Fly    75 VELRPFSTQLLHFEIPALRTDRYRLTAEGLGGVQ--FTNETQLHF-ESKQHTV-------LVQTD 129

Mouse   136 KPVYTPDQSVKIRVYSLGDDLKPAKRETVLTFIDPEGSEVDIVEEND----------YTGIISFP 190
            |.:|.|...|..||..|..:||||:....:        .|||.:..|          .|..|...
  Fly   130 KSIYKPGDLVHYRVLILDANLKPARGYGRV--------HVDIKDSGDNIIRSYKDIRLTNSIYSN 186

Mouse   191 DFKIPSNPKYGVWTIKANYK-KDFTTTGTAYFEIKEYVLPRFSVSIELERTFIGYKNFKNFEITV 254
            :.::..:|::|.|:|..:.. ::.|.|    |||.:::||:|.|.|:..:..| ||:.| ...||
  Fly   187 ELRLSDSPRFGTWSIVVDVSDQEHTQT----FEILDHILPKFVVDIDTPKHAI-YKDGK-IAATV 245

Mouse   255 KARY-FYNKVVPDA--EVY-AFFG-LREDIKDEEKQMMHKATQAAKLVDGVAQISFDSETAVKEL 314
            :|.| |...:|.:|  .:| .||| |:..:.|       ..|:....:||.|...||.|   .||
  Fly   246 RAHYAFGQPIVGEATLSIYPTFFGSLQPFVND-------LITRKVVPIDGNAYFEFDIE---NEL 300

Mouse   315 SYNSLEDLNNKYLYIAVTVTESSGGFSEEAEIPGVKYVLSPYTLNLVATPLFVKPGIPFSIKAQV 379
            ...  :|...:||..|:...:|:|.....:.:  :...|:.|.:..|..|.:..||:||...|::
  Fly   301 HLK--QDYERQYLLDALVEEKSTGSVQNYSTV--LTLHLNHYRVEAVKVPSYYIPGVPFEATARI 361

Mouse   380 KDSLEQAVGGVPVTLMAQTVDVNQE----------TSDLETKRSITHDTDGVAVFVLNLP----- 429
                .:..||       |..|.|.:          :|::..:.:.:.|..|.......:|     
  Fly   362 ----ARNDGG-------QLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRD 415

Mouse   430 --SNVTVLKFEIRTDDPELPEENQASKEYEAVAYSSLSQSYIYIAWTENYKPMLVGEYLNIMVTP 492
              .::.|....:.::..::|.::..||.|             ..|...|.:| .|.:.::::|..
  Fly   416 EFHSIIVDYQGVISEVGKIPSKHLHSKNY-------------ITAKVLNDRP-TVNQEISVVVRS 466

Mouse   493 KSPYIDKITHYNYLILSKGKIVQYGTREKLFSSTYQNINIPVTQNMVPSARLLVYYIVTGEQTAE 557
            .:|    |.::.|.::.:|.|: ......:...|:..|....:..|:|.|.||||.::.|    |
  Fly   467 FAP----IKYFMYQVVGRGDII-LSRNVDVAPGTFHTIKFLASFAMMPRANLLVYTVIDG----E 522

Mouse   558 LVADAVWINIEEKCGNQLQVHL---SPDEYVYSPGQTVSLDMVTEADSWVALSAVDRAVYKVQGN 619
            .|.|...|.:||...|.:||..   :|      |||.:.:.:.|:..|:|.|..||:....::..
  Fly   523 FVYDEQVIQLEENLLNAVQVDAPIRAP------PGQDIDIGISTKPYSYVGLMLVDQNANDLRSG 581

Mouse   620 AKRAMQRVFQALD--EKSDLGCGAGGGHDNADVFHLAGLTFLTNANADDSHYRDDSCKEILRSKR 682
            .....:|:..||.  |.||:....|.....:.|..::...:.....|:.:...|   :|:.....
  Fly   582 HDLTHKRLMDALRSYELSDVNTPMGSPGKESGVITMSNTDYFIEKEAESNPALD---REVSTGPE 643

Mouse   683 NLHLLRQKIEEQAAKYKHSVPKKCCYDGARVNFYETCEERVARVTIGPLCIRAFNECCTIANKIR 747
            ...|                                  ..|.:..|||                 
  Fly   644 EDKL----------------------------------TTVRKTDIGP----------------- 657

Mouse   748 KESPHKPVQLGRIHIKTLLPVMKADIRSYFP----------------ESWLW-----------EI 785
               .||      |.:.||.|.......||.|                ::||:           .|
  Fly   658 ---AHK------IEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDPADTWLFLNISASSDGRNSI 713

Mouse   786 HRVPKRKQLQVTLPDSLTTW--------EIQGIGIS-DNGICVADTLKAKVFKEVFLEMNIPYSV 841
            ||         .:|..:|:|        .:.|:|:| .||       |.:.:||.::...:|||:
  Fly   714 HR---------RIPSEMTSWVVSAFALDPVNGLGLSPPNG-------KLEAYKEFYISTELPYSI 762

Mouse   842 VRGEQIQLKGTVYNYMTSGTKFCVKMSAVEGICTSGSSAASLH--------TSRPSRCVFQR--- 895
            .|.|.|.:...|:|...|.....|         |..:||....        |::|...:::|   
  Fly   763 KRDELIAIPFVVHNNRDSDLNVEV---------TFYNSALDFDFPQLDPKATNQPKVELYRRRSL 818

Mouse   896 -IEGSSSHLVTFTLLPLEIGLHSINFSLETSFGKDILVKTLRVVPEGVKRESYAGVILDPKGIRG 959
             :.|.|:..|:|.:.|..:|...:.....:|...|.:.:.|.|...|.......|.:.:   :..
  Fly   819 QVPGRSARSVSFIVTPKRVGPLLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLFE---LNS 880

Mouse   960 IVNRRKEFPYRIPLDLVPK-TKVERILSVKGLLVGEFLSTVLSKEGINILTHLPKGSAEAELMSI 1023
            ....|:.....:|.:.:|: |::|  :|..|.|:|..:.      .::.|..||.|..|..:::.
  Fly   881 NAQNRRNVTIAVPRNAIPESTRIE--VSAVGDLIGSLVG------NLDSLILLPTGCGEQTMVNF 937

Mouse  1024 APVFYVFHYLEAGNHWNIFYPDTLSKRQSLEKKIKQ--------GVVSVMSYRNADYSYSMWKGA 1080
            .|...|..|              |.:.:.|..:::.        |...::.||:.:.::|.: |.
  Fly   938 VPNLIVLRY--------------LGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAF-GL 987

Mouse  1081 S---ASTWLTAFALRVLGQVAKYVKQDENSICNSLLWLVEKCQLENGSFKENSQYLPIKLQGTLP 1142
            .   :||||||:..|.|.|.|.:.:.|.|.:..:|.:| ...|..||.|:|         :|.:.
  Fly   988 DIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYL-GSVQSANGGFEE---------RGDVF 1042

Mouse  1143 AEAQEKTLYLTAFSVIGIRKAVDICPTMK--IHTALDKADSFLLENTLPSKSTFTLAIVAYALSL 1205
            ....:..:.||||..:.:.:.||:.|..:  |:.|||    |:......|.:...:||..|.||.
  Fly  1043 ERFGDDGISLTAFVTLALMENVDLYPEYRNNINKALD----FITRGLDGSSNLHAMAIGTYVLSR 1103

Mouse  1206 GDRTHPRF---RLIVSALRKEAFVKGDPPIYRYWRDTLKRPDSSVP--SSGTAGMVETTAYALLA 1265
            .:......   ||...|..|:..        ::|..|....:...|  ::..:..:|.:|||.||
  Fly  1104 ANHNAKAAFLQRLDSMATNKDGL--------KWWNKTAPAGEQQSPWYNATRSVNIEISAYAALA 1160

Mouse  1266 SLKLKDMNYANPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLLKQIHLDMDINVAYKHEGD 1330
            .|:...:..|.|::.||.:::...|||.::|||:..::.|..::........::.|...| .||.
  Fly  1161 LLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAERFSSQGNNLQIGFHY-GEGA 1224

Mouse  1331 FHKYKVTEKHFLG-RPVEV--SLNDDLVVSTGYSSGLATVYVKTVVHKISVSEEFCSFYLKIDTQ 1392
            .....|..::.|. :.||:  :|.:..|.:||....||.|   :..:..:|:..:..|.|   ..
  Fly  1225 ETIINVNAENSLALQTVELPNNLKNLSVSATGRGMALAQV---SYTYNTNVTSAWPRFVL---DP 1283

Mouse  1393 DIEASSHFRLSDSGFKRIIACASYKPSKEESTSGSSHAVMDISLPTGIGANEEDLRALVEGVDQL 1457
            .:..:||     :.:..:.||||:.....|:...|:.|||::.||:|...:.:.|..|.......
  Fly  1284 TVNRNSH-----ADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIK 1343

Mouse  1458 LTDYQIKDGHVILQLNSIPSRDFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMIYSISDT 1522
            ..:.|.::..|::..:.:..|: :|.....::..:|....|....:|:|:...::....|....:
  Fly  1344 KVETQNRNTKVVIYFDYLDRRE-VCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKS 1407

Mouse  1523 RLQKVCEGAACTCVEADCAQLQAEVDLAISADSRKEKACKPETAYA 1568
            .:..:||.|.|.             ||...|:.|:.|.....||.|
  Fly  1408 NICDICEHANCG-------------DLCEKAEKRESKRPDDYTAIA 1440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HcXP_017171158.1 MG1 27..124 CDD:375333 27/102 (26%)
A2M_N 130..223 CDD:376626 26/103 (25%)
MG3 225..309 CDD:375334 28/88 (32%)
MG4 358..461 CDD:375332 21/119 (18%)
A2M_N_2 474..614 CDD:377903 38/142 (27%)
ANATO 690..758 CDD:237984 6/67 (9%)
A2M 780..867 CDD:365945 26/106 (25%)
complement_C3_C4_C5 1003..1308 CDD:239226 78/322 (24%)
A2M_recep 1427..1517 CDD:369460 17/89 (19%)
NTR_like 1535..1683 CDD:382999 8/34 (24%)
Tep3NP_523507.2 A2M_N 124..215 CDD:280081 25/109 (23%)
A2M_N_2 448..573 CDD:285005 37/140 (26%)
A2M 697..787 CDD:278630 26/114 (23%)
A2M_2 918..1203 CDD:239227 78/321 (24%)
A2M_comp 967..1200 CDD:284982 67/255 (26%)
A2M_recep 1313..1402 CDD:284981 17/89 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167840004
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
54.800

Return to query results.
Submit another query.