DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hand1 and twi

DIOPT Version :9

Sequence 1:	NP_032239.1	Gene:	Hand1 / 15110	MGIID:	103577	Length:	216	Species:	Mus musculus
Sequence 2:	NP_001033967.1	Gene:	twi / 37655	FlyBaseID:	FBgn0003900	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	146	Identity:	49/146 - (33%)
Similarity:	73/146 - (50%)	Gaps:	16/146 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse    46 LLSPADAAPDFPAGGPPPTTAVAAAAY-GPDARPSQSPGRLEALGSRLPKRKGSGPKKERRRTES 109
            ::|||..|.|..||.....:.....|: .|..|..:.|.:.|.. .....::.....:||:||:|
  Fly   314 VMSPACLADDGSAGSLLDGSDAGGKAFRKPRRRLKRKPSKTEET-DEFSNQRVMANVRERQRTQS 377

Mouse   110 INSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVL---------AKDAQAGDPEAF--- 162
            :|.||..|::.||.:|:| |||||:||:|||.||.:|..:|         |.:|| |.|.|:
  Fly   378 LNDAFKSLQQIIPTLPSD-KLSKIQTLKLATRYIDFLCRMLSSSDISLLKALEAQ-GSPSAYGSA 440

Mouse   163 KAELKKTDGGRESKRK 178
            .:.|.....|.|:..|
  Fly   441 SSLLSAAANGAEADLK 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hand1	NP_032239.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..109		13/56 (23%)
		HLH	103..152	CDD:197674	27/57 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..203		4/14 (29%)
twi	NP_001033967.1	HLH	363..413	CDD:278439	25/50 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839651
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.800