Protein Alignment CTSE and CG5860

DIOPT Version :10

• Sequence 1: XP_011507546.1
• Gene: CTSE / 1510
• HGNCID: 2530
• Length: 401
• Species: Homo sapiens
• Sequence 2: NP_650622.1
• Gene: CG5860 / 42095
• FlyBaseID: FBgn0038506
• Length: 370
• Species: Drosophila melanogaster
• Alignment Length: 416
• Identity: 139/416 - (33%)
• Similarity: 214/416 - (51%)
• Gaps: 64/416 - (15%)

Human     1 MKTLLLLLLVLLELGEAQGSLHRVPL--RRHPSLKKKLRARS--------QLSEFWKSHNLDMIQ 55
            |..:|..||..|.|..|...:.:|||  ||..:..:...|||        ||....::||
  Fly     1 MLRVLCFLLAFLSLVFATQKILKVPLYVRRSFNESEVFLARSATEGGETLQLQLLLQTHN----- 60

Human    56 FTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHS 118
                               :|||:|||::|:|.|||||||||||||.|:|||.|  ::.||:.|.
  Fly    61 -------------------NMEYYGTIAMGNPRQNFTVIFDTGSSNTWLPSVNCPMSNSACQNHR 106

Human   119 RFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFSYQVEGLTVVGQQFGESVTEPGQTFVD 183
            ::..|:||:|...|::|:::||:|.:.|.:..|     :..:.|..:....||||:......|..
  Fly   107 KYNSSRSSSYIPDGRNFTLRYGSGMVVGYLSKD-----TMHIAGAELPHFTFGESLFLQHFAFSS 166

Human   184 AEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSG 248
            .:|||::|||...|:....||..:.:.||.|::..:||||:..:|.     |::|||:|.|.|.|
  Fly   167 VKFDGLVGLGLGVLSWSNTTPFLELLCAQRLLEKCVFSVYLRRDPR-----EIVFGGFDESKFEG 226

Human   249 SLNWVPVTKQAYW--QIALDNI---QVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGA 308
            .|::|||::...|  ||:..::   |:||.       ..||:||||||:..|......|.|.:.|
  Fly   227 KLHYVPVSQWHTWSLQISKSSVGTKQIGGK-------SNAILDTGTSLVLVPQQTYHNLLNTLSA 284

Human   309 APVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLW 373
            ...:|.:.|.|.: ..:|::...|....:.|:.:.|.:...:|....|.     |.|.|.....|
  Fly   285 KLQNGYFVVACKS-GSLPNINILIGDKVFPLTSSDYIMEVLLDRKPACV-----LAIAPINRGFW 343

Human   374 ILGDVFIRQFYSVFDRGNNRVGLAPA 399
            :|||:|:|::|:|||....|:|||.|
  Fly   344 VLGDIFLRRYYTVFDATEKRIGLAKA 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSE	XP_011507546.1	A1_Propeptide	23..49	CDD:462326	10/35 (29%)
		Cathespin_E	78..398	CDD:133153	116/326 (36%)
CG5860	NP_650622.1	Asp	63..369	CDD:394983	118/328 (36%)