Protein Alignment CTSE and CG17134

DIOPT Version :10

• Sequence 1: XP_011507546.1
• Gene: CTSE / 1510
• HGNCID: 2530
• Length: 401
• Species: Homo sapiens
• Sequence 2: NP_609458.1
• Gene: CG17134 / 34494
• FlyBaseID: FBgn0032304
• Length: 391
• Species: Drosophila melanogaster
• Alignment Length: 405
• Identity: 174/405 - (42%)
• Similarity: 244/405 - (60%)
• Gaps: 34/405 - (8%)

Human     5 LLLLLVLLELGEAQGSLHRVPL-------RRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSM 62
            ||:||||:.:|.:...|:||.|       :.|.|:|.:....:....|     |....|:.|.|
  Fly     4 LLVLLVLVGIGHSAAKLNRVQLQVNKNFTKTHGSVKAEKTVLASKYSF-----LAETSFSVSSS- 62

Human    63 DQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
              .|.|.|.|.::.||:|.|:||:|.|.|.::|||||:||||||..|  ::.||:.|:::..|.|
  Fly    63 --GATENLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNKYDSSAS 125

Human   126 STYSQPGQSFSIQYGTGSLSGIIGADQVSAFSYQVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 190
            |||...|:.|:|:||||||||.:..|.|:     :.|:::..|.|||:::|||.|||||.|.|||
  Fly   126 STYVANGEEFAIEYGTGSLSGFLSNDIVT-----IAGISIQNQTFGEALSEPGTTFVDAPFAGIL 185

Human   191 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPV 255
            ||.:.::||.||||.||||::|.|:|.|:.|.|:........|.|||.||.|.|.:.|||.:|||
  Fly   186 GLAFSAIAVDGVTPPFDNMISQGLLDEPVISFYLKRQGTAVRGGELILGGIDSSLYRGSLTYVPV 250

Human   256 TKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECA 320
            :..||||..::.|:..||:: |: |||||.|||||||..|....:::...:||...|||..|.|.
  Fly   251 SVPAYWQFKVNTIKTNGTLL-CN-GCQAIADTGTSLIAVPLAAYRKINRQLGATDNDGEAFVRCG 313

Human   321 NLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGF---QGLDIHPPAGPLWILGDVFIRQ 382
            .::.:|.|...|.|..:||:|..|.:....:|..:|.|.|   :||.       .||||||||.:
  Fly   314 RVSSLPKVNLNIGGTVFTLAPRDYIVKVTQNGQTYCMSAFTYMEGLS-------FWILGDVFIGK 371

Human   383 FYSVFDRGNNRVGLA 397
            ||:|||:||.|:|.|
  Fly   372 FYTVFDKGNERIGFA 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSE	XP_011507546.1	A1_Propeptide	23..49	CDD:462326	7/32 (22%)
		Cathespin_E	78..398	CDD:133153	150/325 (46%)
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:472175	151/329 (46%)