Protein Alignment CTSE and CG6508

DIOPT Version :10

• Sequence 1: XP_011507546.1
• Gene: CTSE / 1510
• HGNCID: 2530
• Length: 401
• Species: Homo sapiens
• Sequence 2: NP_609457.1
• Gene: CG6508 / 34493
• FlyBaseID: FBgn0032303
• Length: 423
• Species: Drosophila melanogaster
• Alignment Length: 408
• Identity: 160/408 - (39%)
• Similarity: 233/408 - (57%)
• Gaps: 42/408 - (10%)

Human     4 LLLLLLVLLELGEAQGSLHRVPLRR-------HPSLKKK---LRARSQLSEFWKSHNLDMIQFTE 58
            |:::.|.||.|..:.|.|.|.|:.|       |.::|.:   |.|:..|.:...|....:
  Fly     6 LIIIPLFLLLLDHSMGQLRRTPITRQINQNKTHANVKAEKILLAAKYFLVDRQSSQTTQV----- 65

Human    59 SCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQ 121
                       |.|..::||...:.||:|||.|.:.||||||:||||||.|  |:.||:.|:::.
  Fly    66 -----------LANGFNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYN 119

Human   122 PSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFSYQVEGLTVVGQQFGESVTEPGQTFVDAEF 186
            .|.||::.:.|:.||||||:|||||.:..|.|     .::|:.:..|.|.|::.|||..||:..|
  Fly   120 SSASSSHVEDGKGFSIQYGSGSLSGFLSTDTV-----DIDGMVIRNQTFAEAIDEPGSAFVNTIF 179

Human   187 DGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLN 251
            |||:|:.:.|:: ||||..|||::.|.||..|:||||:..:....:|.|:|:||.|.|.:.|.:|
  Fly   180 DGIIGMAFASIS-GGVTTPFDNIIRQGLVKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGCIN 243

Human   252 WVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPV-DGEY 315
            :|||:..||||...:::::.| ::.|: |||||.|||||||..|....|.:...:.|... |||.
  Fly   244 YVPVSMPAYWQFTANSVKIEG-ILLCN-GCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEA 306

Human   316 AVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQ-FCSSGFQGLDIHPPAGPLWILGDVF 379
            .|:|::|..:|:|...|.|..|||:|..|......|..| .|.|||..|.    ...||||||:|
  Fly   307 FVDCSSLCRLPNVNLNIGGTTYTLTPKDYIYKVQADNNQTLCLSGFTYLQ----GNLLWILGDIF 367

Human   380 IRQFYSVFDRGNNRVGLA 397
            :.:.|:|||.|..|:|.|
  Fly   368 LGKVYTVFDVGKERIGFA 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSE	XP_011507546.1	A1_Propeptide	23..49	CDD:462326	8/35 (23%)
		Cathespin_E	78..398	CDD:133153	141/324 (44%)
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:472175	143/330 (43%)