DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTSE and Bace

DIOPT Version :9

Sequence 1:	XP_011507546.1	Gene:	CTSE / 1510	HGNCID:	2530	Length:	401	Species:	Homo sapiens
Sequence 2:	NP_001285756.1	Gene:	Bace / 34182	FlyBaseID:	FBgn0032049	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	399	Identity:	180/399 - (45%)
Similarity:	241/399 - (60%)	Gaps:	33/399 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     2 KTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSA 66
            ||:.:::| |..|..|:  |||||:.:..:..|  ..::.|:|  ||:.....|.....|:|:
  Fly     3 KTIAVVVL-LAALASAE--LHRVPILKEQNFVK--TRQNVLAE--KSYLRTKYQLPSLRSVDE-- 58

Human    67 KEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQP 131
             |.|.|.::|.|:|.||||:|.|:|.|:||:|||||||||..|.|.||.||:::..|.||||...
  Fly    59 -EQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVAN 122

Human   132 GQSFSIQYGTGSLSGIIGADQVSAFSYQVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPS 196
            |:|||||||||||:|.:..|.|     .|.||::..|.|.||..|||..|.||.||||||:.|.|
  Fly   123 GESFSIQYGTGSLTGYLSTDTV-----DVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYES 182

Human   197 LAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYW 261
            |||.||.|.|.||::|.|||..:||.|::.:.....|.||||||.|.|.:||:|.:||:::|.||
  Fly   183 LAVDGVAPPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYW 247

Human   262 QIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMP 326
            |..:....:.| ...|.: ||||.|||||||..|.:....|...:.... ||  .::|::::.:|
  Fly   248 QFTMAGSSIDG-YSLCDD-CQAIADTGTSLIVAPYNAYITLSEILNVGE-DG--YLDCSSVSSLP 307

Human   327 DVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQ--GLDIHPPAGPLWILGDVFIRQFYSVFDR 389
            ||||.|.|..:.|.|:||.:..  ||.  |.|.|:  |.|       .||||||||.|:|:.||.
  Fly   308 DVTFNIGGTNFVLKPSAYIIQS--DGN--CMSAFEYMGTD-------FWILGDVFIGQYYTEFDL 361

Human   390 GNNRVGLAP 398
            ||||:|.||
  Fly   362 GNNRIGFAP 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTSE	XP_011507546.1	A1_Propeptide	21..49	CDD:285240	9/27 (33%)
		Asp	77..399	CDD:278455	157/324 (48%)
		Cathespin_E	78..398	CDD:133153	155/321 (48%)
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	159/330 (48%)
Bace	NP_001285756.1	Asp	68..371	CDD:278455	157/324 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151459
Domainoid	1	1.000	297	1.000	Domainoid score	I1463
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2536
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		mtm8487
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1428
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.940