Protein Alignment CTSE and CG31661

DIOPT Version :10

• Sequence 1: XP_011507546.1
• Gene: CTSE / 1510
• HGNCID: 2530
• Length: 401
• Species: Homo sapiens
• Sequence 2: NP_722707.1
• Gene: CG31661 / 33330
• FlyBaseID: FBgn0051661
• Length: 393
• Species: Drosophila melanogaster
• Alignment Length: 421
• Identity: 141/421 - (33%)
• Similarity: 203/421 - (48%)
• Gaps: 51/421 - (12%)

Human     1 MKTLLLLLLVLLELGEAQGSLHRVPLRRH-------PSLKKKLRARSQLSE---FWKSHNLDMIQ 55
            ::.::||..:::.:|..:  :||..|.|.       |.....|:.|:.|..   |.....::.:.
  Fly     3 IRVIILLFCLIVFVGGKK--VHRFRLERRSHRHHKIPHAHLHLQFRNALRRKYGFTPLRTVNAVN 65

Human    56 FTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKT--HS 118
            .|..........|||||..|..:||.:|:|.  |:||:.||||||:.||||.:|.. ..||  :.
  Fly    66 VTSESGKGVVITEPLINSYDTNFFGVVSVGD--QSFTMQFDTGSSDFWVPSSHCRF-CIKTCGNK 127

Human   119 RFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQV--SAFSYQVEGLTVVGQQFGESVTEPGQTF 181
            .|:.|.|.::...|..|||.||:||:.||:.:|.|  .....|.:|:.:|......||
  Fly   128 FFRKSNSKSFRSSGTPFSITYGSGSVKGIVASDNVGFGDLKIQNQGIGLVNISDSCSV------- 185

Human   182 VDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHF 246
                ||||.|..:..|::....|.|..|:.|.||:.|:||.::.|....| || :|.||.:.|.:
  Fly   186 ----FDGIAGFAFQQLSMTKSVPSFQQMIDQQLVEQPIFSFHLKSGSSDG-GS-MILGGSNSSLY 244

Human   247 SGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSE-GCQAIVDTGTSLITGPSDKIKQLQNAIGAA- 309
            .|.|.:..||:..||...||.|.|.|.....|. |.:||:|||||||.||..::..:...|||.
  Fly   245 YGPLTYTNVTEAKYWSFKLDFIAVHGKGSRSSRTGNKAIMDTGTSLIVGPVLEVLYINKDIGAEH 309

Human   310 -PVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTL-LDFVDGMQFCSSGFQ---GLDIHPPA 369
             .....|.|.|.::..:|.:.|.|.|..:.:.|..|.: .|     .||.|.|.   ||.
  Fly   310 NKTYNLYTVACESIPQLPIIVFGIAGKEFFVKPHTYVIRYD-----NFCFSAFMDMLGLQ----- 364

Human   370 GPLWILGDVFIRQFYSVFDRGNNRVGLAPAV 400
              .|||||.|:|:.|..||....|:|:||||
  Fly   365 --YWILGDAFMRENYVEFDWARRRMGIAPAV 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSE	XP_011507546.1	A1_Propeptide	23..49	CDD:462326	8/35 (23%)
		Cathespin_E	78..398	CDD:133153	118/330 (36%)
CG31661	NP_722707.1	Asp	88..392	CDD:394983	119/331 (36%)