DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTSD and cathD

DIOPT Version :9

Sequence 1:	NP_001900.1	Gene:	CTSD / 1509	HGNCID:	2529	Length:	412	Species:	Homo sapiens
Sequence 2:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	218/417 - (52%)
Similarity:	279/417 - (66%)	Gaps:	34/417 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MQPSSLLPLALCLLAAPA-------SALVRIPLHKFTSIRRTMSEVGGSVEDL-IAKGPVSKYSQ 57
            ||..:||.:|. |.||.|       ..|:|:|||||.|.||..::||..::.| |..|
  Fly     1 MQKVALLLVAF-LAAAVAHPNSQEKPGLLRVPLHKFQSARRHFADVGTELQQLRIRYG------- 57

Human    58 AVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHK 122
                  .|.:||.|.|||||||||.|.||:|||.|.||||||||||||||..|.|.:|||.:|:|
  Fly    58 ------GGDVPEPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNK 116

Human   123 YNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPG 187
            |::.||.||.||||.|.|.|||||||||||.||||:           .|:.::.|.|.||..:||
  Fly   117 YDASKSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSI-----------AGLDIKDQTFAEALSEPG 170

Human   188 ITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDS 252
            :.|:|||||||||:.|..|||:.|.|.|..:.:|.|:...:|||||:|||.:..|||::.||:|.
  Fly   171 LVFVAAKFDGILGLGYNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDP 235

Human   253 KYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGA 317
            .:|.|..:||.||||||||:.:|...:.. |.|||.||:.|.||||||:..|::|...:.:.||.
  Fly   236 NHYTGEFTYLPVTRKAYWQIKMDAASIGD-LQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGG 299

Human   318 VPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPL 382
            .|:|.|:|::.|:.:..||.|...||||.::|..:||.|:|:|.|||:|||||||:|||||:|||
  Fly   300 TPIIGGQYVVSCDLIPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPL 364

Human   383 WILGDVFIGRYYTVFDRDNNRVGFAEA 409
            |||||||||:|||.||..|:|||||:|
  Fly   365 WILGDVFIGKYYTEFDMGNDRVGFADA 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTSD	NP_001900.1	A1_Propeptide	22..49	CDD:400357	13/27 (48%)
CTSD	NP_001900.1	Cathepsin_D2	73..408	CDD:133157	188/334 (56%)
cathD	NP_001334713.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147035
Domainoid	1	1.000	390	1.000	Domainoid score	I789
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55616
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1750
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		otm40751
orthoMCL	1	0.900	-	-		OOG6_100536
Panther	1	1.100	-	-	LDO	PTHR47966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3883
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800