Protein Alignment CTSD and CG5860

DIOPT Version :10

• Sequence 1: NP_001900.1
• Gene: CTSD / 1509
• HGNCID: 2529
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_650622.1
• Gene: CG5860 / 42095
• FlyBaseID: FBgn0038506
• Length: 370
• Species: Drosophila melanogaster
• Alignment Length: 409
• Identity: 136/409 - (33%)
• Similarity: 217/409 - (53%)
• Gaps: 54/409 - (13%)

Human    11 LCLLAA------PASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEG---- 65
            ||.|.|      ....::::||:    :||:.:|    .|..:|:           :.|||
  Fly     5 LCFLLAFLSLVFATQKILKVPLY----VRRSFNE----SEVFLAR-----------SATEGGETL 50

Human    66 PIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
            .:..:|:.:.:.:|||.|.:|.|.|.|||:|||||||.|:||::|.:.:.||..|.||||.:||:
  Fly    51 QLQLLLQTHNNMEYYGTIAMGNPRQNFTVIFDTGSSNTWLPSVNCPMSNSACQNHRKYNSSRSSS 115

Human   131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKF 195
            |:.:|.:|.:.||||.:.||||:||:.:           .|.::....|||:.......|.:.||
  Fly   116 YIPDGRNFTLRYGSGMVVGYLSKDTMHI-----------AGAELPHFTFGESLFLQHFAFSSVKF 169

Human   196 DGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLS 260
            ||::|:....:|.:|..|..:.|..|:|:::.:||.||.|||     .|::.||.|...::|.|.
  Fly   170 DGLVGLGLGVLSWSNTTPFLELLCAQRLLEKCVFSVYLRRDP-----REIVFGGFDESKFEGKLH 229

Human   261 YLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEY 325
            |:.|::...|.:.:.:..|  |.........||:||||||::.|......|...:.| .|..|.:
  Fly   230 YVPVSQWHTWSLQISKSSV--GTKQIGGKSNAILDTGTSLVLVPQQTYHNLLNTLSA-KLQNGYF 291

Human   326 MIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFI 390
            ::.| |..:||.|.:.:|.|.:.|:..||.::|....|..|:     :.|.|.:...|:|||:|:
  Fly   292 VVAC-KSGSLPNINILIGDKVFPLTSSDYIMEVLLDRKPACV-----LAIAPINRGFWVLGDIFL 350

Human   391 GRYYTVFDRDNNRVGFAEA 409
            .|||||||....|:|.|:|
  Fly   351 RRYYTVFDATEKRIGLAKA 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSD	NP_001900.1	A1_Propeptide	23..49	CDD:462326	6/25 (24%)
		Cathepsin_D2	73..408	CDD:133157	119/334 (36%)
CG5860	NP_650622.1	Asp	63..369	CDD:394983	120/330 (36%)